Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis
- Conditions
- ScoliosisAdolescent Scoliosis
- Interventions
- Other: aerobic exerciseOther: combined exerciseDevice: treadmill
- Registration Number
- NCT02413788
- Lead Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
- Brief Summary
Inflammatory markers have been analyzed in several diseases of unknown etiology, in the expectation of increasing therapeutic perspectives. This possibility arises from the different levels of tissue injury with low-grade chronic inflammation that have been observed in studies in which the markers were not evaluated traditionally, and today have influenced clinical management.
The investigators aimed, therefore, to evaluate the inflammatory markers in patients with AIS before and after aerobic and combined exercise training.
- Detailed Description
Inflammatory markers have not been evaluated in adolescent idiopathic scoliosis (AIS), but this deformity potentially involves various musculoskeletal structures permanently, which justifies the analysis. A low-grade chronic inflammation may be related to the lower capacity in exercise performance observed in this population, which must be stimulated to perform standardized physical activity.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- thoracic curvature ≥ 45 degrees
- indication for surgical treatment of spinal deformity
- absence of pulmonary, cardiac, articular or neurological disorder, atopic dermatitis and previous or current allergy
- agree part in the research with a assent statement and the person responsible with the consent form and informed
- acknowledged chronic liver or kidney inflammatory disease
- use of corticosteroids, acetylsalicylic acid or other nonhormonal anti-inflammatory clinical or laboratorial evidence of infection
- severe obesity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description aerobic group (treadmill) aerobic exercise 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) for 36 sessions combined group (treadmill and resisted) combined exercise - 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) and resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs (36 sessions) combined group (treadmill and resisted) treadmill - 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) and resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs (36 sessions) aerobic group (treadmill) treadmill 10 minutes of warming, aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate) for 36 sessions
- Primary Outcome Measures
Name Time Method interleukin 8 change from baseline in interleukin 8 at 3 months Inflammatory Markers
interleukin 1 change from baseline in interleukin 1 at 3 months Inflammatory Markers
interleukin 6 change from baseline in interleukin 6 at 3 months Inflammatory Markers
- Secondary Outcome Measures
Name Time Method oxygen saturation in six-minute walk test change from baseline in oxygen saturation at 3 months analysis of oxygen saturation at end of test
distance in six-minute walk test change from baseline in distance at 3 months analysis of distance
systolic blood pressure in six-minute walk test change from baseline in systolic blood pressure at 3 months analysis of systolic blood pressure at end of test
heart rate in six-minute walk test change from baseline in heart rate at 3 months analysis of heart rate at end of test
respiratory frequency in six-minute walk test change from baseline in respiratory frequency at 3 months analysis of respiratory frequency at end of test
peak expiratory flow change from baseline at 3 months peak expiratory flow variation analysis in liters / minute (l/min)
forced vital capacity (FVC) change from baseline at 3 months analyzed in liters or % of predicted of lung capacity variation from baseline at 3 months
FORCED EXPIRATORY FRACTION (FEF25-75%) change from baseline at 3 months analyzed in milliliters (ml) of lung volume variation from baseline at 3 months
diastolic blood pressure in six-minute walk test change from baseline in diastolic blood pressure at 3 months analysis of diastolic blood pressure at end of test
forced expiratory volume in the first second (FEV1) change from baseline at 3 months analyzed in liters or % of predicted of lung volume variation from baseline at 3 months
forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) change from baseline at 3 months Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months
Borg scale in six-minute walk test change from baseline in Borg scale at 3 months analysis of Borg scale at end of test
maximal inspiratory pressure (MIP) change from baseline at 3 months analysis of maximal inspiratory pressure variation (cmH2O)
maximal expiratory pressure (MEP) change from baseline at 3 months analysis of maximal expiratory pressure variation (cmH2O)
FORCED EXPIRATORY FRACTION (FEF25-75%) / forced vital capacity (FVC) change from baseline at 3 months Analysis (%) of the relationship between FEV1 and FVC with variation from baseline at 3 months
Trial Locations
- Locations (1)
Santa Casa of Sao Paulo Medical School
🇧🇷Sao Paulo, Brazil