Evidence-based Modeling for Acquired Dyslexia Treatments
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 12
- 试验地点
- 3
- 主要终点
- Woodcock Reading Mastery Test - III
研究概览
简要总结
This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fluent in English as a first language pre-stroke by self report.
- •Normal or corrected-to-normal vision.
- •Normal or aided hearing.
- •Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
- •Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.
排除标准
- •Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
- •Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
- •History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
- •Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.
研究组 & 干预措施
Model-matched
This group will receive the therapy, either phonological or semantics-based, that matches the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy, and for the second 60 hours of therapy.
干预措施: Phono-Motor Therapy (Behavioral)
Model-matched
This group will receive the therapy, either phonological or semantics-based, that matches the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy, and for the second 60 hours of therapy.
干预措施: Semantic Feature Analysis (Behavioral)
Model-non-matched
This group will receive the therapy, either phonological or semantics-based, that does not match the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy. For the second 60 hours, they will receive the other therapy.
干预措施: Phono-Motor Therapy (Behavioral)
Model-non-matched
This group will receive the therapy, either phonological or semantics-based, that does not match the computational model prediction for the source of their reading impairment. They will receive this for the first 60 total hours of therapy. For the second 60 hours, they will receive the other therapy.
干预措施: Semantic Feature Analysis (Behavioral)
结局指标
主要结局
Woodcock Reading Mastery Test - III
时间窗: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.
The WRMT-III is a standardized measure of reading skills.
Test words and pseudowords
时间窗: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.
Change in accuracy of reading 120 test words and 80 pseudowords
次要结局
- Western Aphasia Battery - Revised(Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.)
- Comprehensive Aphasia Test - Disability Quotient(Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.)
研究者
William W. Graves, Ph.D.
Associate Professor
Rutgers, The State University of New Jersey