Acquired Dyslexia Modeling and Treatment

Not Applicable

Not yet recruiting

• Conditions: Stroke; Dyslexia, Acquired

• Registration Number: NCT07209488
• Lead Sponsor: Rutgers, The State University of New Jersey

Brief Summary

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-10
• Study First Submitted: 2025-10-02
• Study First Submitted QC: 2025-10-02
• Last Update Submitted: 2025-10-02
• Study First Posted: 2025-10-07
• Last Update Posted: 2025-10-07
• Study Start: 2025-11-01
• Primary Completion: 2026-09
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Fluent in English as a first language pre-stroke by self report.
• Normal or corrected-to-normal vision.
• Normal or aided hearing.
• Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
• Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.

Exclusion Criteria

• Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
• Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
• History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
• Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Woodcock Reading Mastery Test - III	Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.	The WRMT-III is a standardized measure of reading skills.
Test words and pseudowords	Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.	Change in accuracy of reading 120 test words and 80 pseudowords

Secondary Outcome Measures

Name	Time	Method
Western Aphasia Battery - Revised	Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.	The WAB - R is a standard measure of aphasia severity. It determines both the degree of aphasia and whether treatment has any impact on aspects of aphasia other than acquired dyslexia.
Comprehensive Aphasia Test - Disability Quotient	Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.	The CAT - DQ is a self-report measure of subjectively perceived degree of disability.

Trial Locations

Locations (3)

Florida State University; 🇺🇸 Tallahassee, Florida, United States

Johns Hopkins University School of Medicine; 🇺🇸 Baltimore, Maryland, United States

Kessler Foundation; 🇺🇸 West Orange, New Jersey, United States