TCTR20190515002尚未招募未知
Comparison between non-switching and early-switching therapy to aflibercept in diabetic macula edema with suboptimal response to prior treatment with bevacizumab.
/A0 个研究点目标入组 110 人开始时间: 2019年5月15日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- 入组人数
- 110
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 100 Years（—）
- 性别
- All
入选标准
- •- Patient with center-involved DME with suboptimal response to 3 monthly initial bevacizumab
- •injections (defined as persistent DME in central fovea, intraretinal cystoid space or subretinal
- •fluid persisted, with central subfield thickness ≥305 microns in women and ≥320 microns in
- •men by Heidelberg Spectralis OCT after 3 consecutive injection of bevacizumab)
- •- Age > 18 years old
- •- Visual acuity 6/7.5 †6/240 (20/25 †20/800)
- •- No history of prior intravitreal injections or laser to treat macular edema
排除标准
- •- Patients with other disorders affecting macular thickness such as retinal vein occlusion,
- •vitreomacular traction, epiretinal membrane, macular hole, choroidal neovascularization and
- •medication known to cause macular edema
- •- Patients with active proliferative diabetic retinopathy and neovascular glaucoma
- •- Patients with ocular media opacity that preclude OCT imaging
- •- Patients who cannot comply to the 3 monthly follow-up visits
- •- Patients with recent onset of thromboembolic events such as stroke and myocardial infarction
- •within 6 months
- •- Pregnant women
研究者
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