Treatment of Clinical Depression in Overweight & Obese Adults: A Tailored Cognitive Behavioural Approach.

Not Applicable

• Conditions: Clinical Depression; Overweight/Obesity; Inflammation; Mental Health - Depression; Diet and Nutrition - Obesity; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12614001324606
• Lead Sponsor: ick Buckley

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. DSM Diagnosis of depression
2. Overweight or Obese (BMI: 25-35)
3. Willing and able to participate in exercise intervention
4. Older than 18 years of age, younger than 45 years of age.
5. Stable use of antidepressents (at least 3 weeks on regular dose)
6. No current engagement in therapy and willingness to postpone new therapy for the duration of participation
7. If female, must not be pregnant or attempting to become pregnant.
8. Understand written and spoken English (a conversational level of english is all that is required)

Exclusion Criteria

1. Specific psychological disorders (Psychosis, Personality Disorder or Bipolar Disorders - either ICD-10 or DSM)
2. Previous cardiovascular incident (e.g. heart attack, stroke)
3. Current cardiovascular disease (i.e. CHD)
4. Serious or unstable medical conditions (other than obesity)
5. Substance dependence requiring rehabilitation/detoxification
6. Current suicidal ideation or recent attempt (previous 24months)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
% Change in Depression level as measured on the BDI-II<br>[Measured fortnightly from week 0 to 10 and at follow up one and three months post treatment.];% Change in Depression, Anxiety and Stress Scores as measured on the DASS-21[Measured every 5 weeks, 0, 5 and 10 and then at follow up at one month and 3 months post treatment.]

Secondary Outcome Measures

Name	Time	Method
% Change in inflammation as measured by finger prick blood sample (i.e. CRP, IL-6, TNF-a, IL-1, Interferon-y and IL-4)[Measured at Week 0 and Week 10.];% Change in Eating behaviours as measured on the Intuitive Eating Scale-23 and Binge Eating Scale[Week 0, 5, 10 and follow up at one and three months post treatment.];% Change in Self efficacy as measured by the New General Self Efficacy Scale and Exercise Self Efficacy Scale[Week 0, 5, 10 and one and three month follow up post treatment.];% Change in Self compassion and body image as measured by the Self Compassion Scale and Physical Self Description Questionnaire[Week 0, 5, 10 and at one month and three months post treatment.];% Change in body fat measured by DEXA[Week 0 and Week 10.]