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Clinical Trials/NCT03410888
NCT03410888
Completed
Not Applicable

Popliteal Approach to Sciatic Nerve Block Provides Postoperative Analgesia That Is Not Inferior to That of the Infragluteal Approach in Patients Undergoing Unilateral Total Knee Arthroplasty Under Spinal Anesthesia

University Health Network, Toronto1 site in 1 country16 target enrollmentAugust 2011

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Neuromuscular Blockade
Sponsor
University Health Network, Toronto
Enrollment
16
Locations
1
Primary Endpoint
Visual analogue pain scores. The score at 6 hours will be considered as primary outcome.
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

Study Hypothesis The investigators approach to demonstrate noninferiority of analgesia provided by popliteal block in TKA surgery will be based on a hypothesis of absence of a clinically significant difference in pain visual analogue sores (VAS) between the analgesia provided by the popliteal block and that of the infragluteal sciatic block in TKA surgery patients.

Detailed Description

Sciatic nerve block provides clinically significant analgesic benefits following total knee arthroplasty (TKA). These benefits include a reduction in pain scores and decrease analgesic requirements. Despite these benefits, sciatic nerve block has remained among the least performed peripheral nerve block by anesthesiologists. Some impediments relating to single shot sciatic nerve block (SSNB) that may cause anesthesiologists to avoid it include, patient discomfort due to needle passage through dense gluteal or thigh adipose and musculature, and unreliable success because of difficulty in localizing the sciatic nerve (particularly in obese patients). Even in the current era of US guidance, sciatic nerve block remains a challenge. Despite its helpfulness, ultrasound technology remains hindered by an intrinsic limitation: a trade off between depth of penetration and image resolution; therefore, it works well for superficial blocks but becomes less useful when deep structures are imaged-ironically where this guidance is needed most. The challenge of anatomical depth, as in the case of the sciatic nerve, is one remaining challenge that dictates practical restrictions on the patterns of practice of ultrasound-guided regional anesthesia. Actually, the recommendations of the Joint Committee for Education and Training composed of the American Society of Regional Anesthesia and the European Society of Regional Anesthesia cite the depth of block resulting in degradation of both ultrasound and needle image as the first among other causes that increase the level of difficulty of a nerve block. As the sciatic nerve travels caudally in the body, it becomes more superficial with less thickness of tissue separating it from skin surface, making distal sciatic nerve block an attractive alternative. Indeed, both articular branches which provide sensory innervation to the knee joint as well as its muscular branches which provide innervation to the muscles surrounding knee joint most commonly arise from the sciatic nerve either at the knee level, or just above the knee or within the popliteal fossa. Blockade of the sciatic nerve at the level of the popliteal fossa, commonly termed a popliteal block, is technically easier to perform than gluteal sciatic block and may even be associated with less risk of intravascular injection and nerve injury. Indeed, popliteal block has been reported to provide good postoperative analgesia in total knee replacement and other major knee surgery. However, the small posterior cutaneous nerve of the thigh, which supplies only the skin on the back of the thigh and knee, separates from the sciatic nerve proximally and variably in the gluteal region, and will be spared in more distal approaches. It is for this reason why many practitioners are hesitant to perform distal sciatic nerve blocks for TKA. However, the relative importance of the posterior cutaneous nerve of the thigh for post-operative analgesia following TKA is unknown and maybe clinically insignificant.

Registry
clinicaltrials.gov
Start Date
August 2011
End Date
January 2012
Last Updated
8 years ago
Study Type
Interventional
Study Design
Factorial
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • English speaking
  • American Society of Anesthesiologists (ASA) Physical Status Scale I-III patients undergoing unilateral TKA under spinal anesthesia and nerve blocks
  • Ages 18-85
  • BMI ≤ 38 kg/m2

Exclusion Criteria

  • Chronic pain disorders
  • Significant pre-existing neurological deficits or peripheral neuropathy affecting the lower extremity
  • Abuse of drugs or alcohol
  • Allergies to any medication included in the study protocol
  • Contraindication to spinal anesthesia or failure to institute spinal anesthesia after performing femoral and sciatic blocks
  • Bilateral TKA surgeries
  • History of significant psychiatric conditions that may affect patient assessment
  • Pregnancy

Outcomes

Primary Outcomes

Visual analogue pain scores. The score at 6 hours will be considered as primary outcome.

Time Frame: 6 hours

Overall pain level as well as pain localized o the back of the knee will be assessed at rest and on movement (knee flexion) and will be quantified with a 100 mm VAS pain scale score, with 0 representing no pain and 100 representing the worst imaginable pain.

Secondary Outcomes

  • Sensory/Motor block onset assesment in the sciatic nerve distribution(60 minutes)

Study Sites (1)

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