The Effect of Eating Frequency on Blood Pressure

Not Applicable

Withdrawn

• Conditions: Blood Pressure
• Interventions: Other: dietary intervention

• Registration Number: NCT01640015
• Lead Sponsor: Imperial College London

Brief Summary

The primary purpose of this study is to identify the effect of meal frequency on blood pressure (BP) levels of individuals.

Detailed Description

Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels.

Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2012-01
• Study Completion: 2012-03
• Study First Submitted: 2012-07-11
• Study First Submitted QC: 2012-07-12
• Study First Posted: 2012-07-13
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-16
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers

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Exclusion Criteria

• Weight change of ≥ 3kg in the preceding 2 months
• Current smokers
• Substance abuse
• Alcohol intake
• Pregnancy
• Diabetes
• Cardiovascular disease
• Cancer
• Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
• Kidney disease
• Liver disease
• Pancreatitis
• Use of medications including: anti inflammatory drugs or steroids, antihypertensive drugs, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High frequency diet	dietary intervention	-
low frequency diet	dietary intervention	Participants will be assigned to a low frequency diet (fixed energy intake)

Primary Outcome Measures

Name	Time	Method
blood pressure	2 weeks for 24 hours through blood pressure monitor	Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center.

Secondary Outcome Measures

Name	Time	Method
Insulin	measured twice during each phase (2 phases)	biomarkers like: Insulin - Glucose- lipid profile- Free fatty acids- C peptides- HS CRP will be measured regularly during study

Trial Locations

Locations (1)

Sir John Michael Center - Hammersmith Hospital; 🇬🇧 London, United Kingdom