The Effect of Number of Eating Episodes Per Day on Blood Pressure. A Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- blood pressure
研究概览
简要总结
The primary purpose of this study is to identify the effect of meal frequency on blood pressure (BP) levels of individuals.
详细描述
Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels.
Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers
排除标准
- •Weight change of ≥ 3kg in the preceding 2 months
- •Current smokers
- •Substance abuse
- •Alcohol intake
- •Pregnancy
- •Cardiovascular disease
- •Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
- •Kidney disease
- •Liver disease
- •Pancreatitis
- •Use of medications including: anti inflammatory drugs or steroids, antihypertensive drugs, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.
研究组 & 干预措施
low frequency diet
Participants will be assigned to a low frequency diet (fixed energy intake)
干预措施: dietary intervention (Other)
High frequency diet
干预措施: dietary intervention (Other)
结局指标
主要结局
blood pressure
时间窗: 2 weeks for 24 hours through blood pressure monitor
Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center.
次要结局
- Insulin(measured twice during each phase (2 phases))