Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery

Not Applicable

Active, not recruiting

• Conditions: Stroke; Visual Impairment; Parkinson Disease
• Interventions: Other: Cross-frequency dual-site tACS

• Registration Number: NCT05220449
• Lead Sponsor: Ecole Polytechnique Fédérale de Lausanne

Brief Summary

This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients suffering from visual field defects.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-01
• Study First Submitted: 2021-11-30
• Study First Submitted QC: 2022-01-27
• Study First Posted: 2022-02-02
• Primary Completion: 2023-08-01
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-27
• Last Update Posted: 2024-08-28
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. the patient can consent for themselves;
2. age 18+ years old;
3. at least 7 days since diagnosis "stroke".
4. Patients should demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field

Exclusion Criteria

1. Diminished capacity to consent;
2. Pregnancy
3. Known or suspected non-compliance, drug or alcohol abuse
4. Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant,
5. Non-compliance to the instructions of the experimenter or an inappropriate behavior hindering the normal progress of the experiment.
6. Previous enrolment into the current study
7. Exclusion criteria of MRI, tACS, TMS
8. Use of psychoactive medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Cf-tACS (V1-Gamma_V5-Alpha)	Cross-frequency dual-site tACS	-
Cf-tACS (V1-Alpha_V5-Gamma)	Cross-frequency dual-site tACS	-

Primary Outcome Measures

Name	Time	Method
Changes in visual field functions	Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)	Comparison of the systematic measurement of the visual field using Humphrey perimetry

Secondary Outcome Measures

Name	Time	Method
Changes in inter-areal cross-frequency interaction	Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)	Comparison of the inter-areal Alpha-Gamma coupling using electroencephalography recordings
Changes in visual tracts integrity	Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)	Comparison of the diffusion weigted imaging-based tractography of the main visual tracts
Changes in motion discrimination and integration performances	Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)	Comparison of the motion coherence threshold extracted from a two forced-choice direction discrimination task
Changes in functional connectivity within the broad visual network	Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)	Functional MRI based connectivity analyses using DCM or graph theory will perfomed

Trial Locations

Locations (1)

Campus Biotech, EPFL; 🇨🇭 Geneva, Switzerland