The role of persistent gastrointestinal viral infections in the development of enteropathy in children with Common Variable Immunodeficiency and secundary immunodeficiencies - Chronic gastrointestinal viruses in immunocompromised children

niversitair Medisch Centrum Utrecht0 个研究点目标入组 155 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•CVID: diagnosed according to the ESID criteria:
•Normal to low numbers of B lymphocytes.
•Impaired specific antibody production after immunisation (less than 4-fold titer increase after polysaccharide vaccination)
•Low (<-2SD) serum immunoglobulin titers.
•CVID-like disease: patients who do not fulfill the ESID criteria for CVID, but suffer from a similar clinical picture: at least one of the serum immunoglobulin(subclasses) is decreased (<-2SD), or there is insufficient antibody synthesis after immunisation less than 4-fold titer increase after polysaccharide vaccination). Secondly, patients suffer from recurrent infections, for which they are or have been treated with immunoglobulin substitution therapy for at least 6 months.
•Healthy children: age 4-18 years
•SCT patients: children aged 0-17 who will receive a stem cell transplantation (SCT) at the Wilhelmina Children's Hospital in order to treat their underlying disease, e.g. hematological malignancy, inborn metabolic disease such as Hurler's disease.

•For all patient groups: a proven primary immunodeficiency other than CVID, e.g. X-linked agammaglobulinemia (XLA) or hyper-IgM syndrome (HIGM), or a strong suspicion of one of these diseases.
•For the healthy controls and SCT patients: immune disease, pre-existent gastrointestinal tract disease (e.g. Morbus Crohn, celiac disease, ulcerative colitis)

发起方

niversitair Medisch Centrum Utrecht