Study of Diaphragmatic Ultrasound as a Predictor of Mechanical Ventilation in Patients With Respiratory Diseases on Admission to Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 62
- 主要终点
- estimation of diaphragmatic thickening fraction
研究概览
简要总结
Ultrasonography has been used to explore diaphragmatic contractile activity by measuring thickening fraction .When thickening fraction was < 20% during tidal breathing, it is commonly associated with respiratory failure.
Diaphragmatic ultrasound had been used before as a tool to predict weaning from mechanical ventilation.
In this study diaphragmatic ultrasound will be done upon admission to predict of mechanical ventilation in patients with respiratory diseases.
详细描述
All Patients will be subjected to the following Detailed history taking from patient or relatives including the cause of respiratory diseases.
Complete physical examination: general and local examination will be carried out for all patients.
All cases undergo standard monitoring including invasive and non-invasive blood pressure monitoring, SpO2 and ECG.
Full laboratory investigations: At the beginning of the study (Arterial blood gases, CBC, Coagulation Profile, Kidney function tests, Liver function tests, Cardiac enzymes).
All patients will be treated according to the international guidelines according to their medical status . As well as Hemodynamic support will be provided by fluids resuscitation and/or catecholamine infusion if necessary, to keep mean arterial pressure >70 mmHg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Dyspnea: respiratory rate > 22 breaths per min.
- •Hypoxia: as SO2 < 92% on room air.
- •Hypercapnia: as PaCO2 > 45mmHg.
排除标准
- •Age <18 year.
- •Cardiogenic pulmonary edema.
- •History of interstitial lung disease (fibrosis).
- •Neuromuscular disease.
- •Significant chest wall deformities.
- •Previous diagnosis of diaphragmatic palsy.
- •Recent thoracotomy or sternotomy (within the previous year).
- •Severe hemodynamic instability or shock.
- •Pregnancy.
- •Diagnosis of pneumothorax or pneumo mediastinum.
结局指标
主要结局
estimation of diaphragmatic thickening fraction
时间窗: immediately after intensive care admission
次要结局
- estimation of diaphragmatic excursion(immediately after intensive care admission)
研究者
RAMY AHMED
Assistant Professor of Anesthesia
Ain Shams University