Hippocampal Plasticity of Young Adults With Childhood Adversity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 2
- 主要终点
- Changes in hippocampal subfield gray matter density measured with high resolution structural MRI at 3T
研究概览
简要总结
This study investigates the clinical and neural effects of stress management skill building programs for young adults with childhood adversity. The investigators will recruit a total of 60 young adults (21-35 years old) who will be randomized into two different stress management skill building programs, both of which are 8 weeks long. MRI and psychological assessments will be acquired from all subjects before and after the intervention programs in order to investigate changes in clinical symptoms (such as depression, anxiety and stress) and hippocampus structure and function as well as other neural changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 21 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •having childhood adversity
- •no history of psychiatric disorders of psychotic features or neurological disorders
- •verified age between 21-35 years old;
- •no suicidal attempts during the past six months;
- •being determined by the clinician to have the capability to comply with the program requirements and not detrimental to other participants in the group;
- •passing MRI eligibility criteria.
- •provided written informed consent to participate in this study;
- •committed to meeting the requirement of refraining from using marijuana or illicit drugs.
排除标准
- •psychosis
- •active suicidal attempts during the past 6 months
- •psychoactive substance abuse
- •MRI exclusion criteria
结局指标
主要结局
Changes in hippocampal subfield gray matter density measured with high resolution structural MRI at 3T
时间窗: before and after the 8-week intervention
次要结局
- Changes in severity of depression symptom measured by Beck Depression Inventory (BDI)(before and after the 8-week intervention)
- Changes in stress level measured by the Perceived Stress Scale (PSS)(before and after the 8-week intervention)
- Changes in severity of anxiety symptom measured by State-Trait Anxiety Inventory (STAI)(before and after the 8-week intervention)
研究者
Diane Yan
Assistant Neuroscientist
Mclean Hospital