Ketoconazole and octreotide as medical treatment for Cushing's disease.
Recruiting
- Conditions
- Cushing's diseaseZiekte van Cushing
- Registration Number
- NL-OMON20862
- Lead Sponsor
- Erasmus MC Rotterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Both naïve patients with Cushing’s disease and patients with residual hypercortisolism
after recent transsphenoidal adenomectomy are eligible for enrolment. Finally, patients
with recurrent Cushing’s disease can also be included.
Exclusion Criteria
1. Patients with a disturbed liver function indicated by serum bilirubin, ALAT, ASAT or alkaline phosphatase levels > 2.5 x ULN;
2. Patients with renal insufficiency indicated by serum creatinine levels > 2.0 x ULN;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rinary free cortisol excretion.
- Secondary Outcome Measures
Name Time Method 1. Parameters of coagulation and fibrinolysis;<br /><br>2. Parameters of bone turnover;<br /><br>3. Quality of life.