Comparison of Patient Work of Breathing and Tidal Volumes With High-flow Nasal Cannula Oxygen Therapy and Non-invasive Ventilation After Extubation in the ICU: a Prospective, Randomized, Controlled Study
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 4
- 主要终点
- Patient respiratory effort and tidal volume (Vt)
研究概览
简要总结
This study is aimed at evaluating patient work of breathing and tidal volumes with three methods of oxygenation: standard oxygen, high-flow oxygen therapy and non-invasive ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minimum age: 18 years
- •planned extubation decided by the physician in charge of the patient after success of weaning trial
- •patients at high risk of reintubation according to the following criteria: patient older than 65 years, or those having any underlying chronic cardiac or lung disease
- •Hypoxemia defined by PaO2/FiO2 < 300 mmHg under mechanical ventilation before extubation
排除标准
- •Duration of mechanical ventilation prior to extubation < 24h
- •Contraindication to NIV
- •Contraindication to nasogastric tube
- •Do-not-reintubated order at time of extubation
- •People under legal protection
- •Opposition to participate
研究组 & 干预措施
Group 1
Standard oxygen - High-Flow Nasal Oxygen - Non-invasive ventilation - Standard Oxygen (20 minutes for each condition)
干预措施: High-Flow Nasal Oxygen / Non-invasive ventilation / Standard oxygen (Device)
Group 2
Standard oxygen - Non-invasive ventilation - High-Flow Nasal Oxygen - Standard Oxygen (20 minutes for each condition)
干预措施: High-Flow Nasal Oxygen / Non-invasive ventilation / Standard oxygen (Device)
结局指标
主要结局
Patient respiratory effort and tidal volume (Vt)
时间窗: 1h20
Swing of oesophageal pressure and pressure-Time product measured by a nasogastric pressure sensor tidal Volume estimated by electric impedance tomography
次要结局
- Hemodynamic parameters("Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min")
- Comfort evaluation("Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min")
- Respiratory parameters("Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min")