NCT00955123已完成不适用
Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Patients With Active Ulcerative Colitis and Crohn's Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Functional Hepatic Nitrogen Clearance
研究概览
简要总结
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD). The investigators have earlier shown that the liver plays an important role in this stress-catabolism by increasing the production of urea during the inflammatory process.
The purpose of this study is to examine the effect of the anti-inflammatory drugs prednisolone and infliximab on the regulation of the urea synthesis in patients with active ulcerative colitis and Crohn's disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Moderate to severe active inflammatory bowel disease
排除标准
- •Viral or bacterial infections
- •Other chronical inflammatory diseases
- •Other catabolic diseases
- •Treatment with prednisolone or infliximab within the last 8 weeks
结局指标
主要结局
Functional Hepatic Nitrogen Clearance
时间窗: Before and one week after treatment
次要结局
- Clinical and biochemical measures of inflammation(Before and one week after treatment)
研究者
Karen Louise Thomsen
Dr.
University of Aarhus
研究点 (1)
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