Comparison of the cerebellum in adult very preterm infants versus term infants with 3 and 7 Tesla MRI- correlation with cognitive functions in young adulthood.
Completed
- Conditions
- KOGNITIVEFUNKTIONSEINSCHRNKUNGENP07.1Other low birth weight
- Registration Number
- DRKS00007883
- Lead Sponsor
- niversitätsklinikum EssenZentrum für Kinder- und JugendmedizinKlinik für Kinderheilkunde I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
group of preterm infants: born 24+0 - control group: born >/= 37+0 weeks
Exclusion Criteria
chromosomal abnormalities, neurologic or psychiatric diseases, Epilepsia, intracranial hemorrhage > grade I or periventricular leucomalacia in neonatal period, special educational needs, claustrophobia, metal or active implants, fixed braces, drug or alcohol abuse, sedatives, breastfeeding, pregnant women or those who cannot exclude pregnancy,
relative contraindications: tatoos, steel implants, intrauterine device, permanent make-up
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Volume and structure /substructure of the cerebellum, visualization of lesions, visualization of dentate ncl.
- Secondary Outcome Measures
Name Time Method neurologic examination, <br>Scale for the Assessment and rating of ataxia (SARA, 5th ed.: 8 items: gait, stance, Sitting, speech disturbance, finger chase (dysmetria), nose-finger test (tremor), fast alternating hand movements (diadochokinesia), heel-shin slide), <br>Inventory of Non-Ataxia Symptoms (INAS: Reflexes, Motor Symptoms, sensory Symptoms, opthalmological Findlings) Blinkreflexkonditionierung (Delay-Paradigma), <br>blink reflex conditioning (Delay paradigma), Wechsler Adult Intelligence Test IV (3 IQ-scores: verbal IQ, perceptional reasoning IQ and general ability-IQ and 4 index scores: verbal comprehension, perceptual reasoning, working memory, processing speed), <br>questionaire on life satisfaction (Fragebogen zur Lebenszufriedenheit, 10 items: Health, work, financial situation, leisure time, Partnership and marriage, Relationsship to children, own personality, sexuality, community, living)<br>eyeblink-conditioning