Energy Metabolism for the Patients With Pulmonary Mycobacterium Avium Complex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Relation between energy balance and pulmonary MAC severity
研究概览
简要总结
We aim to examine energy metabolism in patients with pulmonary MAC and clarify the causes of emaciation. We will also investigate the following: the relation between energy metabolism and degree of pulmonary MAC progression; relations among hospitalization, mortality rate, and time-course of changes in energy metabolism; and factors that affect energy metabolism.
详细描述
Patients with pulmonary MAC with a lower BMI than healthy individuals also have a significantly poorer prognosis than those of normal weight. Emaciation in such patients is thought to be caused by destruction of lung structure from disease progression and an increased resting metabolic rate caused by the increased load from breathing; however, causes of emaciation and details of energy metabolism in these patients have not been studied.
Elucidating details of energy metabolism and causes of emaciation in patients with pulmonary MAC could provide the basis for improvement in nutritional status and activities of daily living through early nutrition therapy and rehabilitation. We propose to clarify the following:
Energy metabolism in patients with pulmonary MAC, including resting metabolic rate, calorie intake and consumption, and hormonal secretions.
Relation between energy metabolism and degree of pulmonary MAC progression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with pulmonary MAC.
排除标准
- •Subjects with severe cardiovascular disease, diabetes, neurological disease, renal failure, endocrine disease and malignant neoplasm.
结局指标
主要结局
Relation between energy balance and pulmonary MAC severity
时间窗: Three years
次要结局
- Relation between inflammation (CRP et.) and pulmonary MAC severity(Three years)
- Relation between bone mineral density and pulmonary MAC severity(Three years)
- Relation between hormone secretion and pulmonary MAC severity(Three years)
- Relation between pulmonary function and pulmonary MAC severity(Three years)