Plaque-RADS Combined With Vector Flow Imaging in Assessing Carotid Atherosclerotic Risk
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 855
- 试验地点
- 1
- 主要终点
- the occurrence of symptomatic events
研究概览
简要总结
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed. Ultrasound (US) is one of the most frequently utilized methods in carotid screening worldwide. However, the clinical utility of US-based carotid plaque-RADS in refining stroke risk stratification beyond conventional stenosis grading has not been thoroughly validated. This study intends to conduct a bidirectional cohort study. In the retrospective part, we will collect relevant clinical data of patients and combine the Plaque-RADS scoring system to establish a risk regression prediction model for cardiovascular and cerebrovascular events in patients with carotid plaques. We will also prospectively collect a batch of patient data and incorporate ultrasound vector flow imaging and vascular hardness analysis to conduct a prospective cohort study, and further verify the accuracy and effectiveness of the model. Through this research, we aim to identify high-risk patients early, provide early intervention and treatment for high-risk individuals, and reduce the mortality and disability rates of cardiovascular and cerebrovascular diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with asymptomatic carotid plaques
排除标准
- •suboptimal image quality or insufficiently detailed examination affecting analysis accuracy;
- •recent hemorrhagic cerebral infarction, intracranial hemorrhage, or intracranial neoplasms;
- •a prior history of neck radiotherapy or ipsilateral carotid artery surgical/stent procedures;
- •lost to follow-up monitoring or had an estimated survival time <12 months.
结局指标
主要结局
the occurrence of symptomatic events
时间窗: 12 months after carotid ultrasound examinations
次要结局
未报告次要终点
研究者
Jia Liu
Clinical Professor
Sun Yat-sen University
