跳至主要内容
临床试验/EUCTR2015-002202-37-NL
EUCTR2015-002202-37-NL进行中(未招募)不适用

Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy? - LiO

radboudumc0 个研究点开始时间: 2015年9月21日最近更新:
适应症
相关药物

试验速览

阶段
不适用
状态
进行中(未招募)
发起方
radboudumc

研究概览

简要总结

暂无简介。

研究设计

研究类型
Interventional clinical trial of medicinal product

入排标准

性别
All

入选标准

  • Subjects with stage II to IV colorectal adenocarcinoma, who are scheduled to receive 6-8 cycles of oxaliplatin 130 mg/m2 every 3 weeks .
  • Are the trial subjects under 18? no
  • Number of subjects for this age range:
  • F.1.2 Adults (18-64 years) yes
  • F.1.2.1 Number of subjects for this age range 16
  • F.1.3 Elderly (>=65 years) yes
  • F.1.3.1 Number of subjects for this age range 8

排除标准

  • Receiving other chemotherapeutics in medical history
  • Allergy to amide type of local anesthetics
  • Recent myocardial ischemia (<6 months)
  • Renal function disorders (MDRD < 60)
  • Liver failure (bilirubine > 1,5x upper limit of normal)
  • Adequate hematologic parameters
  • Hypokaliemia
  • Pregnancy or lactating
  • Use of anti-arythmic drugs (flecainide)
  • Pre-existing form of neuropathy (polyneuropathy or small fibre neuropathy)
  • History of chronic pain and opioid use
  • Risk factors for CIPN: alcoholism, diabetes mellitus
  • No written informed consent by patient

研究者

发起方
radboudumc

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