Clinical and Radiological Prognostic Factors of Acute Necrotizing Encephalopathy in Sohag University Hospital

Not yet recruiting

• Conditions: Acute Necrotizing Encephalopathy

• Registration Number: NCT05853159
• Lead Sponsor: Sohag University

Brief Summary

Acute necrotizing encephalopathy of childhood (ANEC) is a fulminant type of encephalopathy. Most reported cases occur in Asian children with the highest prevalence among patients between the age of 6 and 18 months. The most common clinical presentations are fever, rapid alteration in the level of consciousness, and seizures, in addition to characteristic findings in brain imaging that include, but are not limited to, bilateral thalamic lesions with supra and infra-tentorial lesions of variable dimensions.

The diagnosis of ANEC was determined by specific diagnostic criteria as described by Mizuguchi \[1\] which consist of

1. Encephalopathy preceded by viral febrile illness with rapid deterioration in the level of consciousness and convulsions.

2. Absent cerebrospinal fluid (CSF) pleocytosis.

3. Symmetric multifocal brain lesions.

4. Elevation in serum aminotransferase levels.

5. Exclusion of similar diseases. The ANE severity score was used to assess the severity of illness after admission for shock (3 points), brainstem lesions (2 points), age \>4 years (2 points), platelet (PLT) count \< 100,000 (1 point), and elevated CSF protein (1 point) was observed. \[3\] A total score of 9

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2023-04-19
• Status Verified: 2023-05
• Study Start: 2023-05-01
• Study First Submitted QC: 2023-05-07
• Last Update Submitted: 2023-05-07
• Study First Posted: 2023-05-10
• Last Update Posted: 2023-05-10
• Primary Completion: 2024-05-01
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Children aged from 2months up to 12 years admitted to the pediatric emergency department or pediatric ICU presented with Acute encephalopathy & meet diagnostic criteria of acute necrotizing encephalopathy or come for follow up in our outpatient clinic.

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Exclusion Criteria

• Children known to have metabolic disease. Children who have picture of CNS infection & confirmed by CSF analysis.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute necrotizing encephalitis severity score	one year	Clinical and Radiological Prognostic Factors of Acute Necrotizing Encephalopathy in Sohag University Hospital

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt