A 6-week Pilot Study to Investigate the Effects of Protein Hydrolysate From Blue Whiting on Glucose Regulation, Inflammation and Serum Lipids in Elderly Nursing Home Residents From Western Norway
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- Participant compliance
研究概览
简要总结
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population. These age-related changes in muscle function may be explained by chronic low-grade inflammation and insulin resistance. Despite the recommendation of a higher protein intake, little is known about how different protein sources may affect the metabolic health in this population. Analysis of amino acid composition show that fish can be a good protein source for humans. Many fish species are today used as feed ingredients, rather than a protein source for humans. A few studies conducted in humans and rats show that proteins from fish may improve glucose tolerance, reduce inflammation and improve lipid metabolism, indicating that proteins from fish may not only serve as a valuable nutrient but could also hold specific health promoting properties.
The present study will investigate the effects of a protein hydrolysate from blue whiting, a fish species normally used to produce fish meal for aquaculture industry, on glucose homeostasis, inflammation and serum lipids in elderly nursing home residents.
详细描述
Participants receive 6g per day of protein hydrolysate from blue whiting as protein powder mixed with a non-caloric juice for 6 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •>60 years
- •both genders
- •nursing home resident
排除标准
- •life expectancy < 6 months
- •severe cognitive impairment
- •allergies towards fish, milk, egg
- •weight loss >5% last 3 months
结局指标
主要结局
Participant compliance
时间窗: 6 weeks
Investigate the participant compliance based daily registrations by nursing home staff
Participant dropout rate
时间窗: 6 weeks
Number of participants that completed the intervention period
次要结局
- Insulin(6 weeks)
- Monocyte chemoattractant protein-1 in serum(6 weeks)
- Glucose regulation(6 weeks)
- C-reactive protein in serum(6 weeks)
- Interleukin-6 in serum(6 weeks)
研究者
Oddrun Anita Gudbrandsen
Principal Investigator
University of Bergen
