A 6-week Pilot Study to Investigate the Effects of Protein Hydrolysate From Blue Whiting on Glucose Regulation, Inflammation and Serum Lipids in Elderly Nursing Home Residents From Western Norway
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscle Weakness
- Sponsor
- University of Bergen
- Enrollment
- 24
- Primary Endpoint
- Participant compliance
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population. These age-related changes in muscle function may be explained by chronic low-grade inflammation and insulin resistance. Despite the recommendation of a higher protein intake, little is known about how different protein sources may affect the metabolic health in this population. Analysis of amino acid composition show that fish can be a good protein source for humans. Many fish species are today used as feed ingredients, rather than a protein source for humans. A few studies conducted in humans and rats show that proteins from fish may improve glucose tolerance, reduce inflammation and improve lipid metabolism, indicating that proteins from fish may not only serve as a valuable nutrient but could also hold specific health promoting properties.
The present study will investigate the effects of a protein hydrolysate from blue whiting, a fish species normally used to produce fish meal for aquaculture industry, on glucose homeostasis, inflammation and serum lipids in elderly nursing home residents.
Detailed Description
Participants receive 6g per day of protein hydrolysate from blue whiting as protein powder mixed with a non-caloric juice for 6 weeks.
Investigators
Oddrun Anita Gudbrandsen
Principal Investigator
University of Bergen
Eligibility Criteria
Inclusion Criteria
- •\>60 years
- •both genders
- •nursing home resident
Exclusion Criteria
- •life expectancy \< 6 months
- •severe cognitive impairment
- •allergies towards fish, milk, egg
- •weight loss \>5% last 3 months
Outcomes
Primary Outcomes
Participant compliance
Time Frame: 6 weeks
Investigate the participant compliance based daily registrations by nursing home staff
Participant dropout rate
Time Frame: 6 weeks
Number of participants that completed the intervention period
Secondary Outcomes
- Insulin(6 weeks)
- Monocyte chemoattractant protein-1 in serum(6 weeks)
- Glucose regulation(6 weeks)
- C-reactive protein in serum(6 weeks)
- Interleukin-6 in serum(6 weeks)