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临床试验/NCT03529344
NCT03529344已完成不适用

A 6-week Pilot Study to Investigate the Effects of Protein Hydrolysate From Blue Whiting on Glucose Regulation, Inflammation and Serum Lipids in Elderly Nursing Home Residents From Western Norway

University of Bergen0 个研究点目标入组 24 人开始时间: 2016年8月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
24
主要终点
Participant compliance

研究概览

简要总结

The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population. These age-related changes in muscle function may be explained by chronic low-grade inflammation and insulin resistance. Despite the recommendation of a higher protein intake, little is known about how different protein sources may affect the metabolic health in this population. Analysis of amino acid composition show that fish can be a good protein source for humans. Many fish species are today used as feed ingredients, rather than a protein source for humans. A few studies conducted in humans and rats show that proteins from fish may improve glucose tolerance, reduce inflammation and improve lipid metabolism, indicating that proteins from fish may not only serve as a valuable nutrient but could also hold specific health promoting properties.

The present study will investigate the effects of a protein hydrolysate from blue whiting, a fish species normally used to produce fish meal for aquaculture industry, on glucose homeostasis, inflammation and serum lipids in elderly nursing home residents.

详细描述

Participants receive 6g per day of protein hydrolysate from blue whiting as protein powder mixed with a non-caloric juice for 6 weeks.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • >60 years
  • both genders
  • nursing home resident

排除标准

  • life expectancy < 6 months
  • severe cognitive impairment
  • allergies towards fish, milk, egg
  • weight loss >5% last 3 months

结局指标

主要结局

Participant compliance

时间窗: 6 weeks

Investigate the participant compliance based daily registrations by nursing home staff

Participant dropout rate

时间窗: 6 weeks

Number of participants that completed the intervention period

次要结局

  • Insulin(6 weeks)
  • Monocyte chemoattractant protein-1 in serum(6 weeks)
  • Glucose regulation(6 weeks)
  • C-reactive protein in serum(6 weeks)
  • Interleukin-6 in serum(6 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Oddrun Anita Gudbrandsen

Principal Investigator

University of Bergen

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