A Randomized Trial to Establish the Effects of Combination Pill of Losartan Potassium and Hydrochlorothiazide on Medication Compliance Among Patients With High Blood Pressure.
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 207
- 试验地点
- 1
- 主要终点
- Medication compliance
研究概览
简要总结
The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.
详细描述
Despite clear evidence that blood pressure lowering treatment is beneficial for reduction of cardiovascular disease, blood pressure levels are not adequately controlled in many hypertensive patients. More intensive blood pressure lowering treatment is required to achieve maximum reduction of cardiovascular disease. Combination pills of blood pressure lowering drugs could be a safe and effective strategy to achieve blood pressure target but there is no randomized evidence that established the beneficial effects of combination pills of blood pressure lowering drugs. The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 20 years or above
- •Hypertension defined as blood pressure levels of >/=140/90mmHg or current use of blood pressure lowering drugs
- •Able to commence combination therapy of angiotensin receptor antagonists and diuretics
排除标准
- •Blood pressure measurements of >/=200/120mmHg
- •Previous serious adverse events due to angiotensin receptor antagonists or diuretics
- •Known or possible pregnancy
- •Known severe liver dysfunction
- •Known severe kidney disease
- •Known contraindication to angiotensin receptor antagonists or diuretics
- •Taking >/=4 tablets except for angiotensin receptor antagonists
- •ACE inhibitors, thiazide or thiazide-like diuretics in the morning
- •Current participation in another clinical trial
- •A high likelihood that the patient is not suitable for the study treatment
研究组 & 干预措施
Combination pill
Combination pill of losartan potassium 50mg and hydrochlorothiazide 12.5mg in the morning
干预措施: Combination pill of losartan and hydrochlorothiazide (Drug)
结局指标
主要结局
Medication compliance
时间窗: 6 months
次要结局
- blood test(6 months)
- serious adverse events(6 months)
- cost of blood pressure lowering drugs(6 months)
- Blood pressure(6 months)
- adverse events(6 months)