Comparison of requirements for deep neuromuscular block effect during continuous and intermittent bolus injection of rocuronium in patients under general anesthesia
- Conditions
- Not Applicable
- Registration Number
- KCT0006904
- Lead Sponsor
- Kosin University Gospel Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 62
1) Patients aged 18-65 years
2) Patients undergoing general anesthesia for elective abdominal (gastrointestinal tract, colon and rectal, liver) surgery
3) Patients whose operation time is expected to be more than 2 hours
3) Patients corresponding to American Society of Anesthesiologist Status 1-2
1) Patients under total venous anesthesia
2) Emergency surgery patients
3) body mass index = 30 kg/m2
4) Pregnant and lactating women
5) Patients with lung diseases such as asthma and COPD
6) Patients with a history of treatment for cerebrovascular disease
7) Patients allergic to drugs (including neuromuscular blocking agent):
- Patients with a history of hypersensitivity to sevoflurane, desflurane, or other halogenated anesthetics.
- Patients with a history of hypersensitivity to remifentanil and other fentanyl analogues all.
- Patients with a history of hypersensitivity to rocuronium and any of its components or neuromuscular blockers
8) Patients with kidney disease (patients with creatinine clearance less than 60ml/min, patients with renal impairment with a baseline blood creatinine value of 1.5 mg/dL or more)
9) Patients with liver dysfunction
10) Patients with neuromuscular junction disease, including patients with myasthenia gravis and myasthenia gravis
10) Patients who have difficulty in voluntary consent;
11) Patients with a history of psychiatric disorders, including those with difficulty in normal communication
12) Past and family history of malignant hyperthermia or allergy to drugs administered during general anesthesia, and taking drugs known to interact with rocuronium during surgery (some antibiotics, metronidazole, also phenytoin and carbamazepine, diuretics, monoamine oxidase inhibitors, calcium channel blockers, corticosteroids, and those containing magnesium ions).
13) Patients with a history of difficult endotracheal intubation
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total amount of rocuronTotal rocuronium dose for deep neromuscular relaxation during surgery
- Secondary Outcome Measures
Name Time Method Muscle recovery pattern after cessation of rocuronium administration;Time elapsed from administration of muscle relaxation reversal agent to extubation of the endotracheal tube