The effect of dietary interventions on endothelial glycocalyx dimensions and barrier function in South Asian patients with diabetic nephropathy. - Dietary interventions on glycocalyx dimensions in diabetic nephropathy.

eids Universitair Medisch Centrum0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•1. South Asian patient with diabetes mellitus type 2.
•2. Female or male, aged between 18 and 75 years.
•3. Body Mass Index *18.5.
•4. CKD-EPI >45 ml/min/1.73m² at baseline.
•5. Proven microalbuminuria defined as albumin/creatinine ratio *0.3 and <30
•mg/mmol (single portion) or 3-300 mg albumin per day (24 hours urine
•collection) in the last twelve months.
•6. Blood pressure of *180 mmHg with standard antihypertensive care.
•7. Treatment with hypoglycaemic drugs: metformin, sulphonylureas and/or
•8. Subject is willing to participate in the study, must be able to give
•informed consent and the consent must be obtained prior to any study procedure.
•9. Patients must be able to adhere to the study visit schedule and protocol
•requirements.
•10. If female and of child-bearing age, patients must be non-pregnant,
•non-breastfeeding, and use adequate contraception.

•1. Any concurrent illness, disability or clinically significant abnormality
•that may, as judged by the investigator, affect the interpretation of clinical
•efficacy or safety data or prevent the subject from safely completing the
•assessments required by the protocol.
•2. Non-diabetic renal disease e.g. known polycystic kidney disease.
•3. Use of LMW heparin and/or immunosuppressive drugs.
•4. Significant food allergies for galactose, nuts, soy, tomato, corn, grape,
•melon and artichoke, which would make the subject unable to consume the food
•5. Signs of active infection or autoimmune disease, requiring systemic
•6. A psychiatric, addictive or any disorder that compromises ability to give
•truly informed consent for participation in this study.
•7. Malignancy (including lymphoproliferative disease) within the past 2-5 years
•(except for squamous or basal cell carcinoma of the skin that has been treated
•with no evidence of recurrence).
•8. Use of any other investigational drug.
•9. Patient has enrolled another clinical trial within last 4 weeks.

发起方