NL-OMON50642
Completed
Not Applicable
The effect of dietary interventions on endothelial glycocalyx dimensions and barrier function in South Asian patients with diabetic nephropathy. - Dietary interventions on glycocalyx dimensions in diabetic nephropathy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 90
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. South Asian patient with diabetes mellitus type 2\.
- •2\. Female or male, aged between 18 and 75 years.
- •3\. Body Mass Index \*18\.5\.
- •4\. CKD\-EPI \>45 ml/min/1\.73m² at baseline.
- •5\. Proven microalbuminuria defined as albumin/creatinine ratio \*0\.3 and \<30
- •mg/mmol (single portion) or 3\-300 mg albumin per day (24 hours urine
- •collection) in the last twelve months.
- •6\. Blood pressure of \*180 mmHg with standard antihypertensive care.
- •7\. Treatment with hypoglycaemic drugs: metformin, sulphonylureas and/or
- •8\. Subject is willing to participate in the study, must be able to give
Exclusion Criteria
- •1\. Any concurrent illness, disability or clinically significant abnormality
- •that may, as judged by the investigator, affect the interpretation of clinical
- •efficacy or safety data or prevent the subject from safely completing the
- •assessments required by the protocol.
- •2\. Non\-diabetic renal disease e.g. known polycystic kidney disease.
- •3\. Use of LMW heparin and/or immunosuppressive drugs.
- •4\. Significant food allergies for galactose, nuts, soy, tomato, corn, grape,
- •melon and artichoke, which would make the subject unable to consume the food
- •5\. Signs of active infection or autoimmune disease, requiring systemic
- •6\. A psychiatric, addictive or any disorder that compromises ability to give
Outcomes
Primary Outcomes
Not specified
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