NCT06362720尚未招募不适用
The Comparison the CMV Infection and Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation Between Standard Regimen, Methotrexate Plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 158
- 主要终点
- Number of participants with CMV infection and reactivation
研究概览
简要总结
The goal of this observational study is to compare the CMV infection and reactivation after allogeneic hematopoietic stem cell transplantation Between Standard Regimen, Methotrexate plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen. The main questions it aims to answer are:
- How do CMV infection and reactivation differ between Allo-SCT patients who received a standard regimen versus those who received a Post-transplant Cyclophosphamide-based regimen?
- progression-free survival, Median overall survival, cumulative incidence of relapse, non-relapsed mortality (NRM) and GvHD at 2 years after Allo-SCT
- The impact of CMV infection and CMV reactivation on progression-free survival, overall survival, and NRM
- Averse events of GVHD prophylaxis medication Participants will be collected the data of treatment and treatment response during transplant until 2 years after transplant from hospital medical record.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 15 years
- •Diagnosis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome (MDS), myelofibrosis primary and/or post PV/ET myelofibrosis, aplastic anemia, lymphoma, or paroxysmal nocturnal hemoglobinuria
- •Received HLA-matched related (MSD-HSCT) or unrelated allo-SCT (MUD-HSCT) or haploidentical hematopoietic stem cell transplantation
排除标准
- •Insufficient data needed for analysis
结局指标
主要结局
Number of participants with CMV infection and reactivation
时间窗: 14 days to 6 months after transplant
Number of participants with CMV infection and reactivation after allogeneic hematopoietic stem cell transplantation Between Standard Regimen, Methotrexate plus Cyclosporin A, and Post-transplant Cyclophosphamide-based Regimen
次要结局
- GvHD(at 2 years after transplant)
- Averse events(at 2 years after transplant)
- cumulative incidence of relapse(at 2 years after transplant)
- progression-free survival(at 2 years after transplant)
- non-relapsed mortality(at 2 years after transplant)
- Median overall survival(at 2 years after transplant)
研究者
Chutima Kunacheewa
lecturer
Siriraj Hospital
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