ISRCTN56900576
Completed
未知
Functional magnetic resonance lung imaging using inhaled hyperpolarised 129xenon in healthy volunteers and patients with chronic obstructive pulmonary disease
niversity of Nottingham0 sites53 target enrollmentNovember 17, 2015
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Chronic obstructive pulmonary disease
- Sponsor
- niversity of Nottingham
- Enrollment
- 53
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Current participant inclusion criteria as of 22/12/2022:
- •General inclusion criteria:
- •1\. Aged 18 years or over
- •2\. Capacity to give informed consent
- •3\. Normal blood pressure (systolic BP \> 100 mmHg and diastolic BP \> 70 mmHg)
- •4\. Resting heart rate \> 50 bpm
- •5\. For women, negative urinary ß\-hCG at the screening and subsequent visits
- •6\. Subject able to hold breath for 10 seconds
- •7\. Subject able to fit into 129Xe chest coil used for MRI
- •8\. Subject able to understand the requirements of the study and to cooperate with the study procedures
Exclusion Criteria
- •Healthy volunteer exclusion criteria:
- •1\. Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
- •2\. Acute respiratory illness within 30 days of MRI
- •3\. Subject has received an IMP (not including hyperpolarized 129Xe) within 30 days of MRI and administration of 129Xe deemed inappropriate in context of other study
- •4\. Subject deemed unlikely to comply with instructions during imaging
- •5\. Do not meet the inclusion criteria above
- •6\. Subject not deemed fit enough to tolerate procedure
- •7\. Subject deemed unsuitable by clinical investigator for other reasons
- •COPD and IPD patient exclusion criteria:
- •1\. Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
Outcomes
Primary Outcomes
Not specified
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