Physiotherapy Approach for Susac Syndrome

Completed

• Conditions: Susac Syndrome

• Registration Number: NCT06349603
• Lead Sponsor: Rehabilitation Centre Zivot

Brief Summary

Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss. This study presents the case of a patient undergoing intensive physiotherapy intervention following an injury, focusing on assessments such as volume and range of motion measurements, manual muscle tests, and pain intensity evaluations using various scales.

Detailed Description

The patient, aged 17, initially presented with severe limitations in mobility, diagnosed with Susac syndrome. Requiring assistance to walk even short distances due to fear and insecurity. Through a structured physiotherapy program spanning several months, various assessments were conducted, including manual muscle tests and circumference measurements. Significant improvements were observed for muscle function, upper and lower limb circumferences, and performance in mobility tests.

Study Timeline

• Study Start: 2023-02-13
• Primary Completion: 2023-04-01
• Study Completion: 2023-04-06
• Study First Submitted: 2024-03-29
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-04
• Last Update Submitted: 2024-04-04
• Study First Posted: 2024-04-05
• Last Update Posted: 2024-04-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Confirmed diagnosis of Susac syndrome.
• Willingness and ability to participate in a 12-week intensive physiotherapy program.
• Stable medical condition that allows participation in physiotherapy without significant risks.
• Ability to provide informed consent for participation in the study.

Exclusion Criteria

• Presence of severe comorbidities or medical conditions that would interfere with participation in physiotherapy or confound the study outcomes.
• Inability to comprehend or follow the instructions for physiotherapy exercises.
• Pregnancy, as certain physiotherapy modalities may not be suitable during pregnancy.
• Any other condition or circumstance that, in the opinion of the investigator, would compromise the safety or validity of participation in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mobility and Muscle Strength Improvement	Assessed at baseline and after 12 weeks of intensive therapy.	This outcome measure evaluates improvements in mobility in a single individual with Susac syndrome following 12 weeks of intensive physiotherapy. Assessments include the Timed Up and Go test (TUG), which measures the time taken for the individual to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. Progress is indicated by the transition from heavy reliance on assistance for mobility to independent walking for 100 meters.
Muscle Strength Improvement Outcome Measure	Assessed at baseline and after 12 weeks of intensive therapy.	This outcome measure evaluates improvements in muscle strength in a single individual with Susac syndrome following 12 weeks of intensive physiotherapy. Assessments include manual muscle tests (MMT) to assess the strength and function of specific muscle groups, using a standardized grading scale. Progress is indicated by higher grades in manual muscle tests, reflecting improved muscle strength and endurance.
Pain Intensity Outcome Measure	Assessed at baseline and after 12 weeks of intensive therapy.	This outcome measure evaluates changes in pain intensity experienced by the individual with Susac syndrome following 12 weeks of intensive physiotherapy. Pain intensity is assessed using the Visual Analog Scale (VAS), where the individual rates their pain on a scale from 0 to 10, with 0 indicating no pain and 10 indicating the worst possible pain. Progress is indicated by a decrease in VAS scores, reflecting reduced pain intensity.

Trial Locations

Locations (1)

Rehabilitation centre Život; 🇧🇦 Mostar, Bosnia and Herzegovina