Whole Body Vibration Versus Aerobic Training on Interleukin 6 and Endurance After Renal Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- measurement of Interleukin-6
研究概览
简要总结
This study aimed to compare the effect of whole body vibration versus aerobic training on interleukin 6 and endurance after renal transplantation in patients after renal transplantation.
详细描述
Even after a successful renal transplantation, the renal transplant recipients (RTRs) keeps on suffering the consequences of the uremic sickness such as increased cardiovascular risk, elevated level of inflammatory cytokines (IL6), decrease work capacity and quality of life. Since biological and psychological problems are not completely solved by pharmacological treatment, physical training is able both, to improve graft function, work capacity and quality of life, and to reduce cardiovascular risk Therefore, this research aims to investigate effect of the whole-body vibration versus stationary bicycle as modes of aerobic exercises on interleukin 6 in patients and the 6-minutes walk test after renal transplantation, which may reduce the risks of cardiovascular disease, produce improvement of the biology of transplantation, increase of energetic metabolism, and allows for a better quality of life in these subtypes of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of both sexes undergone renal transplantation.
- •Their age will range from 30-45 years old.
- •All patients will have the same medical and nursing care.
- •All the patients will receive a good explanation of treatment and measurement device.
- •They will be free from any genitourinary infections.
- •They will be neurologically free.
排除标准
- •Uncooperative patients
- •Instability of patient's medical condition.
- •Association of another medical problem as heart disease and respiratory problems.
- •Diabetic patients.
- •Patients who have history of medical chronic relevant diseases.
- •Patients who have acute or chronic hepatitis.
- •Patients have pacemaker.
- •Patients who have genitourinary infections.
- •Previous history of epilepsy.
研究组 & 干预措施
whole body vibration
In this group of the study, thirty renal transplant recipients' patients will receive the whole-body vibration for, 20 minutes 3 times per week for 12 weeks after one month post renal transplantation
干预措施: whole body vibration (Device)
stationary bicycle
In this group, thirty renal transplant recipients' patients will receive aerobic exercise on stationary bicycle for 20 minutes 3 times per week for 12 weeks after one month post renal transplantation
干预措施: stationary bicycle (Device)
结局指标
主要结局
measurement of Interleukin-6
时间窗: at baseline and 12 weeks
Before starting the study, the following procedures will be performed. The purpose of the study will be clearly explained to each patient using simple and understandable language, and a written informed consent form will be obtained from each participant as an agreement to be included in the study. A venous blood sample (5 milliliters) will be collected from each subject in a sitting position under standardized conditions. The collected samples will be transferred into sterilized tubes containing tripotassium ethylenediaminetetraacetic acid (K3-EDTA) and heparinized tubes, which will be placed on ice and then kept at room temperature. Serum will be separated from plasma by centrifugation for 10 minutes. Interleukin-6 (IL-6) levels will be measured using the enzyme-linked immunosorbent assay (ELISA) technique with commercially available ELISA kits based on the immunoturbidimetric method. The normal reference range of interleukin-6 (IL-6) is 0-43.5 picograms per milliliter (pg/mL).
次要结局
- assessment of functional capacity(at baseline and 12 weeks)
- assessment of endurance(at baseline and 12 weeks)
研究者
Zeinab Adel Mohamed
Principal Investigator
Cairo University