Evaluation of Hepatic Fibrosis on Multiparametric MRI

Not Applicable

• Conditions: Cirrhosis; Hepatitis
• Interventions: Diagnostic Test: Liver MRI

• Registration Number: NCT03085342
• Lead Sponsor: Seoul National University Hospital

Brief Summary

As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-03-14
• Study First Submitted QC: 2017-03-14
• Study First Posted: 2017-03-21
• Study Start: 2017-04-04
• Primary Completion: 2019-09-25
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-18
• Last Update Posted: 2020-10-20
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...)
• Or transplant recipient for viral hepatitis and on anti-viral agent medication
• AND scheduled for liver resection, biopsy or transient elastography
• AND signed informed consent

Exclusion Criteria

• younger than 18 years
• any contra-indication for contrast-enhanced MRI
• pregnant or nursing women
• biliary obstruction
• unable or unwilling to give informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Liver MRI	Liver MRI	Liver MRI including noncontrast (precontrast) flow measurement, DCE, DWI using multiple b-values, MRE and MR fat quantification.

Primary Outcome Measures

Name	Time	Method
hepatic fibrosis stage	1 month after MRI	F0-1 vs. F2-4 using multiparametric MRI

Secondary Outcome Measures

Name	Time	Method
presence of varix	1 month after MRI	presence of esophageal or gastric varices using multiparametric MRI
comparison of portal flow measurement	1 month after MRI	comparison of portal flow measurement using DCE and precontrast flow measurement

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of