Epidemiology and biology of the metabolic syndrome in adult survivors of childhood cancer.

Recruiting

• Conditions: 10013317; 10003216; 10018424; cardiovascular diseases

• Registration Number: NL-OMON35166
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 1200

Inclusion Criteria

Patient:
- history of childhood cancer
- treated in ErasmusMC-Sophia
- at least 18 years old
- minimum of 5 years after cessation of therapy
Control:
- preferrably brother or sister of the patient, if not available;
- friend or neighbour of survivor of same sex and approximately same age, within a range of 5 years.

Exclusion Criteria

Patient:
- when partly treated in other country
Controls:
- when they also have a history of childhood cancer

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- blood pressure<br /><br>- body composition<br /><br>- (abdominal) obesity<br /><br>- glucose metabolism<br /><br>- lipidspectrum</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-polymorphisms<br /><br>-other parameters associated with the metabolic syndrome:<br /><br>*biomarkers for endothelial function<br /><br>*pro-inflammatory markers<br /><br>*pro-thrombotic factors<br /><br>*biomarkers for adiposity<br /><br>*urine-analysis<br /><br>- results of fitness test</p><br>