Changes of the temporomandibular joint in class III camouflage treatment: CBCT and MRI analysis

Phase 1

Recruiting

• Conditions: Skeletal class III malocclusion in non-growing patients; Class III camouflage treatment,; Cone-beam computed tomography (CBCT),; Magnetic resonance imaging (MRI),; Temporomandibular joint (TMJ),; Condyle,; Articular disc,; Masticatory muscle,; Temporomandibular disorder (TMD),; Quality of Life (QOL),

• Registration Number: TCTR20220316003
• Lead Sponsor: Faculty of Dentistry, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-16
• Study Completion: 2024-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

(Camouflage group) 1. Mild-moderate skeletal class III malocclusion, with CO-CR discrepancy, 2. 18 years of age or above, with complete mandibular growth (CS6), 3. ASA I with healthy general appearance, 4. Willing to receive camouflage treatment

(Surgical group) 1. Skeletal class III malocclusion, treated with bilateral sagittal split ramus osteotomy (BSSRO) completed in 2019-2021, 2. 18 years of age or above, with complete mandibular growth (CS6), 3. ASA I with healthy general appearance

Exclusion Criteria

(Camouflage group) 1. Do not agree to participate and co-operate until the end of the study, 2. Presenting signs and symptoms of TMD, 3. Severe dentofacial deformities, 4. Being diagnosed with psychiatric illness, 5. Planning to get pregnant between 2021-2024, 6. Unable to undergo MRI such as claustrophobia, and having fixed/implanted metal prostheses (can not be removed before MRI)

(Surgical group) 1. Do not agree to participate and co-operate until the end of the study, 2. Presenting signs and symptoms of TMD, 3. Severe congenital deformities in craniofacial region (e.g. cleft lip and palate), 4. Having history of major surgery in craniofacial region (for other purposes which were not to correct skeletal class III), 5. Being diagnosed with psychiatric illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Condyle position around 6-12 months CBCT,TMJ articular disc position around 6-12 months MRI

Secondary Outcome Measures

Name	Time	Method
Thickness and length of masticatory muscles around 6-12 months MRI,Signs and symptoms of TMD every 3 months DC/TMD examination form,TMD-contributing factors every 3 months Questionnaires (Oral behavior checklist, PHQ-9, PHQ-15, GAD-7, GCPS),Oral-health related quality of life every 3 months OHIP-14