Preparing for heat waves - enhancing human thermophysiological resilience.

Recruiting

Conditions: thermoregulation
heat stress
hyperthermia

Registration Number: NL-OMON56773

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

Healthy males and females
60 to 80 years
BMI 25-30 kg/m2
Sedentary (<2h exercise/week)

Exclusion Criteria

• Presence of uncontrolled chronic cardiovascular disease, as determined by
medical history and physical examination
• Participating in a structured exercise program
• Taking hot baths/saunas regularly
• Travelled for a prolonged time to destinations with elevated temperatures the
last 3 months
• Pre-existing T2DM
• Blood donation within a month of study initiation
• People with low hemoglobin concentration (males: Hb = 13.5-17.5 g/dL,
females: Hb = 11.5-15.5 g/dL)
• Recent participation in biomedical study (less than 1 month)
• Using any medication that may influence glucose or lipid metabolism
(beta-blockers, thyroid medications, stimulants, antidepressants,
anticoagulants)
• Smoking or abuse of alcohol
• People with lactose intolerance

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters include thermophysiological parameters (core<br /><br>temperature, skin temperature, and local sweat rate) and cardiovascular markers<br /><br>(heart rate, blood pressure, blood flow).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include metabolic parameters (substrate oxidation,<br /><br>energy expenditure, plasma glucose, insulin, total cholesterol, and free fatty<br /><br>acid concentrations), brain blood flow, endothelial function, and thermal<br /><br>perception (thermal sensation and comfort), and gastrointestinal tolerance. </p><br>