The Effect of Speech and Language Therapy With and Without Transcranial Direct-current Stimulation on Discourse Production in People With Post-stroke Aphasia: a Pilot Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Verb token total
研究概览
简要总结
Aphasia is a language impairment caused by brain injury such as stroke that affects the ability to understand and express language, read and write due to damage in the language regions of the brain. Non-invasive brain stimulation (NIBS) techniques like transcranial direct-current stimulation (tDCS) have been found to improve aphasia treatment effects in post stroke patient populations such as improved naming abilities.
However, the effect of tDCS on more functional, higher level language skills such as discourse production (i.e. story telling, giving instructions) has yet to be understood.Therefore the aim of this study is to determine the potential effectiveness of tDCS as an adjunct to speech and language therapy (SLT) to improve discourse speech production in people with post-stroke aphasia. It is hypothesised that SLT combined with tDCS will result in greater improvements in discourse language production compared to SLT on its own.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aphasia caused by a single stroke
- •at least 6 months post stroke
- •at least 18 years old
- •competent English speaker prior to stroke
- •right handed prior to stroke
- •normal aided or unaided visual acuity
- •willing to participate and to comply with the proposed block of intervention and testing regime.
排除标准
- •Persons with
- •neurological symptoms or history of a neurological event other than their stroke
- •contraindications to tDCS including history of epilepsy or seizures and pacemakers
- •global/severe aphasia
- •cognitive impairment identified by a score less than 20/30 in the Montreal Cognitive Assessment
- •left-handed dominance prior to stroke
- •visual problems which interfere with persons' ability to access visual materials (i.e. pictures)
- •inability to attend sessions
结局指标
主要结局
Verb token total
时间窗: 30 minutes
The number of all verb occurrences in a language sample
Verb type total
时间窗: 30 minutes
The number of distinct verbs in a sample
次要结局
- Total number of utterances(30 minutes)
- Communicative Effectiveness Index (CETI)(10 minutes)
- Total number of words(30 minutes)
- Hospital Anxiety and Depression Scale (HADS)(10 minutes)
- Montreal Cognitive Assessment (MoCA)(15 minutes)
- Aphasia Impact Questionnaire-21 (AIQ)(15 minutes)
- Predicate argument structure (PAS)(30 minutes)