NCT05820802招募中不适用
High Dimensional Analysis of Immune Cells Using scRNA-seq in Pediatric Patients With Allergic Reactions to Neuromuscular Blockers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 294
- 试验地点
- 1
- 主要终点
- Transcriptomic profile analysis of the T lymphocytes by RNA sequencing
研究概览
简要总结
The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing neuromuscular blocking agent, in the event of an allergic reaction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pediatric patients between the ages of 2 and 18 undergoing general anesthesia and surgery using the neuromuscular blocker, rocuronium.
排除标准
- •Patients who have received immunomodulators, immunosuppressants, etc.
- •Patients with autoimmune diseases (rheumatoid arthritis, lupus, Behcet's disease, etc.)
- •Patients who regularly take, or have taken within 4 weeks, medications that may affect the immune system (oral steroids, anti-inflammatories, etc.)
- •Other cases where the Principal Investigator determines that it is difficult to conduct the study.
结局指标
主要结局
Transcriptomic profile analysis of the T lymphocytes by RNA sequencing
时间窗: until end of surgery (usually up to 12 hours from the first dose of rocuronium)
Blood sample from the patients when patient shows allergic reaction after administration of rocuronium
次要结局
未报告次要终点
研究者
Young-Eun Jang
Clinical Associate Professor
Seoul National University Hospital
研究点 (1)
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