To study the correlation of pre emptive analgesia with ibuprofen with post operative IL-6 levels in patients undergoing elective surgeries under general anaesthesia.
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/067317
- Lead Sponsor
- Department of anaesthesia and intensive care GMCH Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients undergoing elective surgery of duration less than 120 minutes under general anaesthesia
Exclusion Criteria
1.Refusal of patients for taking part in the study
2.Patients allergic to ibuprofen
3.Patients with thrombocytopenia
4.Patients with renal impairment
5.Patients with gastric ulcers
6.Patients with severe cardiac, renal and neurological issues.
7.Patients unable to comprehend the post operative pain scores
8.Patients with lateral sinus/ sigmoid sinus/ cavernous sinus thrombosis, petrous apicites, brain abscess
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of pre emptive analgesia with ibuprofen on post operative IL-6 levels in patients undergoing elective surgeries under general anaesthesia.Timepoint: baseline and at 6 hours after the surgery
- Secondary Outcome Measures
Name Time Method 1.To determine IL6 levels in the preoperative and post operative period and draw correlation between them <br/ ><br>2.To calculate the time to first analgesic request and total cumulative dose of post operative analgesic over 24 hours <br/ ><br>3.To evaluate post operative VAS scores and post operative nausea and vomiting at stipulated time intervals <br/ ><br>4.Note any side effect pertaining to the drug administered. <br/ ><br>5.To evaluate post operative hemodynamicsTimepoint: baseline,30 minutes,60 minutes, 6 hours, 12 hours, 24 hours