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Clinical Trials/NCT04941326
NCT04941326
Recruiting
Not Applicable

Investigation of the Effect of Spinal Mobilization and Respiration Techniques on Posture and Respiratory Function in Parkinson's Patients

Abant Izzet Baysal University2 sites in 1 country63 target enrollmentAugust 15, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Parkinson Disease
Sponsor
Abant Izzet Baysal University
Enrollment
63
Locations
2
Primary Endpoint
Pulmonary Function Test
Status
Recruiting
Last Updated
10 months ago

Overview

Brief Summary

Parkinson's patients suffer from respiratory distress for different reasons. It is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. The aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.

Detailed Description

Respiratory complications are one of the most common causes of death in Parkinson's patients. Camptocormia may develop in Parkinson's disease and other pathological conditions involving the basal ganglia, which can be defined as an abnormal flexion of the thoracolumbar spine of 45° or more, which increases during walking or standing and disappears completely in the supine position. Parkinson's patients with camptocormia often complain of dyspnea, which can be attributed to reduced lung capacity due to limited chest expansion. Restrictive changes due to respiratory muscle dysfunction in Parkinson's disease, upper airway obstruction, abnormal ventilatory control, and drug use such as levodopa have an effect on respiratory functions. Restrictive dysfunction has been reported in 28-94% of patients with Parkinson's. Postural disorders such as camptocormia can also lead to restriction. One study found that the lung volumes of Parkinson's disease patients with camptocormia decreased, although it was not associated with major clinical changes. Diaphragmatic dyskinesia in Parkinson's patients may also lead to a restrictive deterioration in respiratory functions. Studies examining the effects of chest and diaphragm mobilization on spirometric parameters in patients with cerebral palsy reported that the applied mobilization and soft tissue techniques improved FEV1 and FVC. The effect of indirect diaphragmatic treatments with vertebral mobilization in individuals with Parkinson's who are at risk of experiencing restrictive respiratory problems is unknown. The aim of this study is to examine the effects of spinal mobilization techniques for the diaphragm on respiratory function parameters and posture.

Registry
clinicaltrials.gov
Start Date
August 15, 2021
End Date
December 1, 2025
Last Updated
10 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Ramazan KURUL

Assistant Professor

Abant Izzet Baysal University

Eligibility Criteria

Inclusion Criteria

  • Have been diagnosed with Parkinson's disease
  • Volunteering to participate in the study
  • Modified Medical Research Council (MMRC) score \>2

Exclusion Criteria

  • Those with COVID-19
  • Diseases that increase intra-abdominal pressure
  • Diseases affecting diaphragmatic motility
  • Those who had a recent thoracic or abdominal operation
  • Those who have a parenchymal, pleural or chest wall mass that will cause restriction on a recent chest X-ray or CT will not be included in the study

Outcomes

Primary Outcomes

Pulmonary Function Test

Time Frame: Four weeks

Respiratory function tests will be performed on all individuals with the MIR SPIROLAB II brand pulmonary function test device. In each measurement, the maneuvers will be repeated at least 3 times and the best values will be recorded. Forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) results from the test will be used to calculate the ratio of FEV1 to FVC (FEV1/FVC) will be recorded. The combined FEV1/FVC ratio will be used as primary outcome.

Secondary Outcomes

  • Spinal Mouse Evaluation(Four weeks)
  • Camptocormia and Range of Motion Evaluations(Four weeks)
  • Ultrasonography(Four weeks)

Study Sites (2)

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