Prospective study to evaluate immunity to SARS-CoV2 in mothers with children in child-care facilities

Completed

• Conditions: U07.1; COVID-19, virus identified

• Registration Number: DRKS00021614
• Lead Sponsor: niversitätsklinikum Rostock

Brief Summary

Background In children, the infection with SARS-CoV-2, the cause of COVID-19, tends to be clinically inapparent more often or less severe than in adults. The spread of this infection from children poses a danger to vulnerable adults. Therefore, child care institutions and schools currently are widely closed. Methods Since the status of infection tends to be congruent in mothers and their children, we tested 401 mothers of children between 1 and 10 years in the city of Rostock (State of Mecklenburg-Westpomerania, northeast of Germany), for the presence of RNA of SARS-CoV-2 in throat swabs, and of antibodies against SARS-CoV-2 in serum. Results In none of the mothers tested, RNA of this virus was detected in the throat swab. In the ELISA test, IgG antibodies were positive in one serum sample, IgA antibodies were positive in 11, and borderline in 3 serum samples. All 401 sera were negative in the indirect immunofluorescence test (IIFT) with FITC-labeled IgG, IgA, und IgM antibodies. Conclusion At the time of this study, neither SARS-CoV-2 RNA, nor specific antibodies against SARS-CoV-2 were detectable in the mothers tested in Rostock.

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-04-22
• Study Start: 2020-06-15
• Results First Posted: 2020-06-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 401

Inclusion Criteria

mothers of children aged 1 to 10 years, who visited child-care facilities. Place of residence: Rostock

Exclusion Criteria

missing informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified