CTRI/2017/07/008996
Recruiting
未知
Carvedilol, Endoscopic Variceal Ligation or combination of both for prevention of First Variceal Bleed in Childâ??s B & C Cirrhosis - A Randomized Controlled Trial
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: null- CirrhosisHealth Condition 2: K746- Other and unspecified cirrhosis ofliver
- Sponsor
- Institute of liver and Biliary Sciences
- Enrollment
- 330
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\) Liver Cirrhotics between 18 to 70 years of age (cirrhosis diagnosed on the basis of clinical, biochemical, fibroscan and imaging.)
- •2\) CTP more than equals to 7 to 15\.
- •3\) Small esophageal varices with RCS and large esophageal varices (more than 5 mm)
- •4\) No history of previous bleed
Exclusion Criteria
- •1\) Malignancy\-HCC, PVT
- •2\) Child A
- •3\) MELD \>35
- •4\) Contraindications to β blockers.
- •5\) Platelet count \< 30,000/mm3
- •6\)Previous endoscopic variceal treatment. (Beyond 21 days)
- •7\) Patients having an indication for TIPS or requiring more than 1 therapeutic ascitic tapping/month
- •8\) Post TIPS, Shunt surgery
- •9\)Acute kidney injury (Sr.Cr \>1\.5mg/dl)
- •10\) Non cirrhotic portal hypertension
Outcomes
Primary Outcomes
Not specified
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