CEREBELLAR INVOLVEMENT IN MOTOR, COGNITIVE AND EMOTIONAL PROCESSES IN MYOCLONUS DYSTONIA
概览
- 阶段
- 不适用
- 干预措施
- DYT-SGCE
- 疾病 / 适应症
- Myoclonus-Dystonia
- 发起方
- Institut National de la Santé Et de la Recherche Médicale, France
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- BOLD signal derived from the functional magnetic resonance imaging
- 状态
- 已完成
- 最后更新
- 3个月前
概览
简要总结
Background:
Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.
Objective:
To investigate the neural correlates of cognition and emotion in DYT-SGCE.
Design:
Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.
Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.
Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.
详细描述
Eligibility: DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.
研究者
入排标准
入选标准
- •For all participants:
- •Age between 15-60 years
- •Able to give informed consent.
- •For patients:
- •An established diagnostic of DYT-SGCE
- •No change in medication (related to DYT-SGCE) for a month
- •For controls:
- •No neurological symptoms
- •No medication except oral contraception
排除标准
- •No deprivation of liberty
- •Inability to give a consent
- •Established cognitive alteration
- •Contraindication to MRI (per MRI safety checklist)
- •Severe chronic psychiatric illness
研究组 & 干预措施
DYT-SGCE
Patients with myoclonus dystonia (DYT-SGCE)
Healthy volunteers
Control group
结局指标
主要结局
BOLD signal derived from the functional magnetic resonance imaging
时间窗: 46 month
Explore the differences in DYT-SGCE compared to HV