Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
- Conditions
- Hypotension on Induction
- Interventions
- Other: Fluid therapy under the guide of Carotid ultrasound
- Registration Number
- NCT05891951
- Lead Sponsor
- Min Su
- Brief Summary
The goal of this clinical trial is to learn about Whether carotid ultrasound guided fluid management can reduce the incidence of hypotension after general anesthesia induction in elderly patients undergoing gastrointestinal surgery.
The main question\[s\] it aims to answer are:
Whether fluid therapy reduces the incidence of general anaesthesia induced hypotension in elderly patients undergoing gastrointestinal surgery.
Whether carotid ultrasound can guide fluid management in elderly patients undergoing gastrointestinal surgery.
Participants will use carotid ultrasound to assess volume status. If volume is insufficient, fluid therapy will be selected until volume is sufficient, anesthesia will be then induced. If volume is sufficient, anesthesia will be directly induced. There is a comparison group: No carotid ultrasound will be used to assess the volume status of the patients, and anesthesia will be directly induced.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
- Age 60-80 years old
- gender unlimited
- ASA: Grade I-Ⅲ
- BMI:18-30kg/㎡
- Patients undergoing elective gastrointestinal surgery under general anesthesia Informed consent
- Carotid artery stenosis ≥50%
- Patients with heart valve disease
- Patients with left ventricular ejection fraction < 50%
- Patients with cardiac dysfunction (NYHA grade Ⅲ-Ⅳ and/or NTproBNP≥900pg/ml)
- Patients Combined with renal insufficiency (creatinine ≥178μmol/L, and/or blood urea nitrogen > 9mmol/L)
- Preoperative systolic blood pressure> 160mmHg or diastolic blood pressure > 100mmHg
- Refuse to participate in the test
- Patients participating in other clinical trials
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description B-Carotid ultrasound guided fluid therapy Fluid therapy under the guide of Carotid ultrasound Participants will use carotid ultrasound to assess volume status. If volume is insufficient, fluid therapy will be selected until volume is sufficient, anesthesia will be then induced. If volume is sufficient, anesthesia will be directly induced.
- Primary Outcome Measures
Name Time Method Occurrence of hypotension after anesthesia induction General anesthesia induction from the beginning to 20 minutes after induction Hypotension occurred from anesthesia induction to 20 minutes after induction in both groups.
- Secondary Outcome Measures
Name Time Method postoperative delirium Within 30 days after surgery Newly diagnosed delirium by the psychiatric department within 30 days after surgery
Postoperative acute kidney injury Within 7 days after surgery Postoperative creatinine increased for a short period of time to more than 0.3mg/dl (26.5μmol/L) or to more than 1.5 times the preoperative creatinine concentration.
postoperative stroke Within 30 days after surgery Any newly diagnosed postoperative neurological dysfunction within 30 days after surgery.
Trial Locations
- Locations (1)
China,Chongqing The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China