NCT06941038已完成不适用
Effect of Intravesical Chemotherapy on Disease Recurrence in Patients Undergoing Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
Ankara Etlik City Hospital1 个研究点 分布在 1 个国家目标入组 270 人开始时间: 2021年6月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- To evaluate the relationship between intravesical chemotherapy administered intraoperatively or postoperatively and bladder recurrence.
研究概览
简要总结
Upper urinary tract urothelial carcinoma (UTUC) accounts for 5%-10% of urothelial malignancies, with up to 50% of patients developing bladder recurrence post-RNU. High-risk UTUC (≥pT2, high-grade, or N+ disease) necessitates aggressive management. Intravesical chemotherapy mitigates recurrence risk, yet optimal timing-intraoperative vs. postoperative-remains unclear. This study evaluates intraoperative epirubicin instillation during RNU compared to postoperative administration and no instillation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •primary high-risk UTUC.
排除标准
- •prior bladder cancer,
- •low-risk UTUC (managed conservatively),
- •metastatic disease,
- •incomplete follow-up
结局指标
主要结局
To evaluate the relationship between intravesical chemotherapy administered intraoperatively or postoperatively and bladder recurrence.
时间窗: 365 days from the first instillation
次要结局
未报告次要终点
研究者
Cagri Akpinar
M.D
Ankara Etlik City Hospital
研究点 (1)
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