study of lab investigations among hospitalized COVID-19 patients

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2020/08/027079
• Lead Sponsor: Dr Swathy Moorthy

Brief Summary

Corona virus disease 2019 is a rapidly spreading viral infection which is now producing a pandemic outbreak affecting all age groups. we have a spectrum of illness varying from mild to severe illness. the clinical and laboratory results of different age groups are different due to the general susceptibility of the disease and presence of associated co-morbid conditions and life style modifications. the laboratory and radiological findings play an important role in the early diagnosis and treatment of monitoring of COVID-19.Real time reverse transcription PCR assays remain the molecular test of choicefor the etiological diagnosis of SARS CoV2. Transaminases the ALT, AST are altered in viral infections. De Ritis ratio (AST/ALT ratio) is more than 1 in cirrhotics and prognosis was related to the level of the ratio. studies revealed that ratio of less than 1 indicated moderate to severe liver damage. Similarly high LDH levels correlated strongly with severe covid pneumonia as per published data. increased creatinine and blood urea levels, elevated D-dimer, decreased total protein and albumin, increased inflammatory markers like CRP, IL-6, Ferritin are also established. We are attempting to see any positive correlations existing between these laboratory parameters whose combination could be a strong predictor for the severity and prognosis of the COVID-9 disease, especially in a resource limited setting.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-17
• Last Update Posted: 2020-10-08

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

all hospitalized COVID-19 patients.

Exclusion Criteria

all hospitalized non COVID-19 patients.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
positive correlation between biomarkers and prognosis, severity of COVID-19 hospitalized patients	at baseline

Secondary Outcome Measures

Name	Time	Method
to see if De Ritis ratio could serve as a prognostic marker for COVID-19 patients	correlation assessed once data is collected

Trial Locations

Locations (1)

SriRamachandra Institute of Higher Education and Research; 🇮🇳 Chennai, TAMIL NADU, India

SriRamachandra Institute of Higher Education and Research

🇮🇳Chennai, TAMIL NADU, India

DrSPThiagarajan

Principal investigator

04445982665

deanresearch@sriramachandra.edu.in