Comparative Accuracy of Activity Scores of Intestinal Ultrasound and Colonoscopy in Monitoring Ulcerative Colitis Activity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Correlation Between Simple Sonographic Activity Scores and Colonoscopy Findings in Active Ulcerative Colitis
研究概览
简要总结
Our study aimed to assess simple sonographic activity scores and Colonoscopy for active UC patients
详细描述
Ulcerative colitis (UC) has a relapsing-remitting course which necessitates frequent follow-up examinations to monitor disease activity.
Disease management was previously guided by patient reported symptoms, and treatment targets were based on symptom control. However, the patient's symptoms do not necessarily correspond to inflammatory activity and current guidelines recommend that management should be based on objective evaluations.
Ileocolonoscopy is considered the reference standard method for determining disease status in Ulcerative colitis. Although validated and reproducible scoring systems are complex and cumbersome to use in clinical practice, and even though ileocolonoscopy is an excellent tool for activity monitoring, it cannot be performed on a regular basis as it is invasive, is resourceintensive and causes considerable patient discomfort. As numerous follow-up examinations are required, simple non-invasive surrogate markers are needed.
Biomarkers such as C-reactive protein [CRP] and faecal calprotectin are well established in both primary work-up and disease monitoring.
Still, as they cannot depict disease location and have limited accuracy, additional tools are required.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient above age of 18 years old and diagnosed to have active UC through:
- •Clinical features: rectal bleeding, with frequent stools and mucous discharge from the rectum. Some patients also describe tenesmus. The onset is typically insidious.
- •Endoscopic findings include the following; loss of vascular pattern, Granular and fragile mucosa, friability, ulcerations, erosions, pseudo-polyposis
排除标准
- •Patients with UC who are under age of 18 years' old.
- •Pregnancy.
- •Previous colectomy.
- •Patient refuse to participate in the study
结局指标
主要结局
Correlation Between Simple Sonographic Activity Scores and Colonoscopy Findings in Active Ulcerative Colitis
时间窗: At baseline (Day 0) from hospital admission
To evaluate the relationship between intestinal ultrasound (IUS)-based sonographic activity scores and endoscopic disease activity assessed by colonoscopy in patients with active ulcerative colitis. The aim is to determine whether sonographic scoring can serve as a non-invasive surrogate for endoscopic assessment in monitoring disease activity.
Assessment of Sonographic Activity Scores Compared to Colonoscopy in Active Ulcerative Colitis Patients
时间窗: At baseline (Day 0 of hospital admission)
To evaluate the diagnostic accuracy and clinical relevance of simple intestinal ultrasound (IUS) activity scores in assessing disease activity in patients with active ulcerative colitis (UC), using colonoscopy findings as the reference standard.
次要结局
未报告次要终点
研究者
Amira Mohammed Abdel Mowgod
Lecturer in Tropical Medicine and Gastroenterology
Assiut University