Adherence Determinants of Medication Non-Adherence Among Patients With Chronic Diseases at Community Pharmacy Settings in Egypt: A Multicenter Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 261
- 试验地点
- 1
- 主要终点
- Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases
研究概览
简要总结
Medication non-adherence among patients with chronic diseases is a major public health concern and is associated with poor disease control, increased complications, and higher healthcare costs. Community pharmacists play an important role in supporting patients' medication use through counseling and education; however, the determinants of medication non-adherence among patients attending community pharmacies in Egypt are not well characterized.
This multicenter, cross-sectional study aims to assess the prevalence of medication non-adherence and identify factors associated with non-adherence among adult Egyptian patients with chronic diseases attending community pharmacy settings. Medication adherence will be evaluated using the Adherence in Chronic Diseases Scale (ACDS), along with sociodemographic, clinical, and medication-related factors. The findings are expected to provide evidence to inform strategies for improving medication adherence and optimizing chronic disease management in community pharmacy practice in Egypt.
详细描述
Chronic diseases represent a substantial burden on healthcare systems and require long-term pharmacological treatment to prevent complications and maintain optimal health outcomes. Effective management of these conditions relies heavily on patients' adherence to prescribed medication regimens. Medication non-adherence is common worldwide and is associated with disease progression, increased hospitalizations, reduced quality of life, and increased healthcare costs.
Community pharmacists are accessible healthcare professionals who are well positioned to support medication adherence through patient education, counseling, and follow-up. Despite this, medication non-adherence remains prevalent, and the factors contributing to non-adherence among patients with chronic diseases in Egypt have not been adequately studied. Sociodemographic characteristics, clinical factors, medication-related issues such as adverse effects, and the availability and quality of pharmacist counseling may all influence adherence behavior.
This study is designed as a multicenter, cross-sectional investigation conducted in community pharmacies across major Egyptian cities, including Cairo, Alexandria, and Giza. The study population includes adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are currently receiving pharmacological treatment for their condition.
Data will be collected using a structured, interviewer-administered questionnaire. Information gathered will include sociodemographic characteristics, clinical and medication history, and exposure to medication counseling. Medication adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated tool for evaluating adherence behaviors in patients with chronic conditions.
The primary outcome of the study is the prevalence of medication non-adherence among patients with chronic diseases attending community pharmacies. Secondary outcomes include identification of factors associated with medication non-adherence, such as medication side effects, patient-related characteristics, and pharmacist-provided counseling. Data analysis will be performed using SPSS software, with binary logistic regression applied to identify significant predictors of medication adherence. Statistical significance will be set at a p-value of less than 0.05.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 80 years.
- •Diagnosed with at least one chronic disease requiring long-term pharmacological treatment.
- •Currently receiving at least one prescribed medication for a chronic condition.
- •Attending a participating community pharmacy during the study period.
- •Able and willing to provide written informed consent.
排除标准
- •Patients with cognitive impairment or mental conditions that limit their ability to understand the study procedures or complete the questionnaire.
- •Patients who refuse or are unable to provide written informed consent.
- •Patients who are acutely ill and unable to participate at the time of data collection.
结局指标
主要结局
Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases
时间窗: Through study completion, an average of 1 month (cross-sectional assessment)
Medication non-adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated questionnaire designed to evaluate patients' adherence behaviors toward prescribed medications for chronic conditions. The outcome will be expressed as the proportion of participants classified as non-adherent and adherent based on ACDS scoring, and analyzed in relation to sociodemographic and clinical factors.
次要结局
- Determinants and Predictors of Medication Non-Adherence in Patients with Chronic Diseases(Through study completion, an average of 1 month (cross-sectional assessment))
研究者
Sarah Sabry Hashem Nafea
Principal Investigator: Assisstant Professor of Pharmacy Practice Faculty of pharmacy and Drug Technology
Egyptian Chinese University