Bone Healing in Immediate Dental Implants

Not Applicable

Completed

• Conditions: Alveolar Bone Loss; Platelet Rich Plasma
• Interventions: Biological: PRP injection; Device: Automated blood cell separator to extract PRP

• Registration Number: NCT04650763
• Lead Sponsor: CMH Lahore Medical And Dental College

Brief Summary

To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

Detailed Description

12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Study Timeline

• Study Start: 2017-10-02
• Primary Completion: 2018-03-30
• Study Completion: 2018-03-30
• Status Verified: 2020-11
• Study First Submitted: 2020-11-14
• Study First Submitted QC: 2020-11-25
• Last Update Submitted: 2020-11-25
• Study First Posted: 2020-12-03
• Last Update Posted: 2020-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction

Exclusion Criteria

• Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PRP Group	Automated blood cell separator to extract PRP	In this group Platelet Rich Plasma (PRP) was injected in soft tissue over surgical site.
PRP Group	PRP injection	In this group Platelet Rich Plasma (PRP) was injected in soft tissue over surgical site.

Primary Outcome Measures

Name	Time	Method
Measurement of bone loss at baseline (12 weeks) and later at 26weeks	Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT	Measurement at mesial in mm

Secondary Outcome Measures

Name	Time	Method
Measurement of bone loss at baseline (12 weeks) and later at 26weeks	Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT	Measurement at distal in mm

Trial Locations

Locations (1)

Institute of Dentistry; CMH Lahore Medical College; 🇵🇰 Lahore, Punjab, Pakistan