Calcium supplementation on blood glucose, lipids and obesity in Chinese wome

Completed

• Conditions: Obesity, blood glucose and lipids; Nutritional, Metabolic, Endocrine; Other nutritional deficiencies

• Registration Number: ISRCTN74325268
• Lead Sponsor: Harbin Medical University (China)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-07
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 400

Inclusion Criteria

1. Aged 30-60 years, healthy female
2. Stable body weight during 6 months before the study

Exclusion Criteria

1. A history of cerebrovascular, cardiovascular, renal, hepatic, diabetes, or other medical diseases likely to interfere with the study
2. Taking medications, which were likely to interfere with the study
3. Received calcium supplements at least for one year before the beginning of the study
4. Pregnant or breast-feeding
5. Information incompleted or unwillingness to attempt to comply with the intervention

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The effects of calcium supplementation on glucose metabolism: fasting glucose and insulin, 2-hour post prandial glucose, Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) and glycated hemoglobin (HbA1c) (%)<br>2. The effects of calcium supplementation on lipids metabolism: <br>2.1. Serum cholesterol, Triglyceride, HDL cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), apolipoprotein A-I (Apo A-I) and Apolipoprotein B (Apo B) <br>2.2. Serum lipoprotein lipase (LPL) and adipocyte fatty acid-binding protein (AFABP) <br>2.3. Serum free fatty acid (FFA) profile <br>3. The effect on obesity: anthropometric indexes<br>4. Serum calcium relative indexes, including parathyroid hormone (PTH), 1.25-hydroxyvitamin D3, serum calcium, thyrocalcitonin and serum phosphate

Secondary Outcome Measures

Name	Time	Method
1. Baseline characteristics: age, gender, body mass index (BMI), blood pressure and physical activity level<br>2. Daily intake of nutrients by the subjects at baseline and after 1 year intervention <br>3. Blood biochemistry characteristics of the subjects at baseline and after 1-year intervention: red blood cell, white blood cell, hemoglobin, total protein, albumin, urea nitrogen, creatinine, alanine transaminase and aspartate transaminase