Study for the prevention of postoperative delirium and postoperative delirium in elderly patients undergoing anesthesia with acupuncture point penetrating point

Not Applicable

• Conditions: Postoperative delirium

• Registration Number: ITMCTR2000003392
• Lead Sponsor: Guangdong Hospital of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients undergoing total knee arthroplasty under general anesthesia;
2. Patients over 65 years old;
3. The American anesthesiologist's Book Writing (ASA) was classified as I-III patients;
4. MMSE score before operation: primary school education >=20 points, middle school education >=22 points, university education >=24 points;
5. Patients who agree to sign informed consent.

Exclusion Criteria

1. Patients with serious psychosis, hematopoietic system disease, malignant tumor and other major diseases;
2. Patients with previous serious heart and lung diseases;
3. Patients taking antipsychotic drugs irregularly for a long time before operation;
4. Patients with obvious hepatorenal diseases or alt, AST higher than 1.5 ULN, Cr, bun higher than ULN;
5. Patients with severe coagulation dysfunction who could not be corrected;
6. Patients with previous history of fainting;
7. Long term alcoholics;
8. Patients with mental disorders or language communication difficulties;
9. Other subjects that the researchers think are not suitable for this study.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of waking or postoperative delirium;

Secondary Outcome Measures

Name	Time	Method
Incidence of vomiting, nausea and postoperative pain;Changes of hypersensitive C-reactive protein, cortisol and neuron-specific enolase NSE;Nu-DESC score;VAS score;CAM-CR score;