Effect of weight reduction on gastroesophageal reflux in obese subjects
Withdrawn
- Conditions
- GERDreflux10017977
- Registration Number
- NL-OMON32499
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
- Men and women > 18 years of age
- BMI > 30 kg/m2
Exclusion Criteria
- Medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, theophylline, calcium blocking agents, opioids)
- Severe concomitant disease
- Extended abdominal surgery in the past
- Present motility disorders
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The change in reflux symptoms and objective measurements of gastroesophageal<br /><br>reflux (time pH < 4, number of reflux episodes) before and after 10% weight<br /><br>loss.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Basal LES pressure<br /><br>- Incidence of TLESR's<br /><br>- Number of acid and non-acid ('weakly acidic') reflux episodes<br /><br>- Symptom Association Probability<br /><br>- Diary Report</p><br>