Association Between COVID-19 and UTIs Caused by ESBL Organism in Infants

Completed

• Conditions: Renal Insufficiency
• Interventions: Other: comparing, prevalence; Other: assessment; Other: evaluation; Other: association

• Registration Number: NCT05630326
• Lead Sponsor: Hamad Medical Corporation

Brief Summary

Urinary tract infections (UTIs) in infants and young children are one of the most common bacterial infections, usually febrile illness without source, frequently due to Enterobacteriaceae, mainly Escherichia coli.

Multidrug-resistant organisms including extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming more prevalent. Due to the risk factors of ESBL-producing organisms in community-acquired (CA)-UTIs in infants in QATAR and Arab countries are still not studied because of the limited therapeutic options. hence, the importance of this study is to get knowledge about how to decrease the rapidly increasing in ESBL- producing bacteria, in infants, and to use antibiotics in a suitable guideline.so, The aim of this retrospective case-control study is to determine the clinical manifestations, and investigations of urinary tract infections among infants and the association with COVID-19 infection, in pediatric emergency centers at Hamad General Hospital - Qatar. From 1st January 2015 till 1st January 2022.

Detailed Description

In this retrospective, case-control study investigators will include all infants (0-1 year) with UTIs who were treated at Hamad General Hospital, pediatric division- PEC Doha, Qatar, using the electronic medical records from 1st January 2015 till January 1st, 2022, diagnosed by a positive urine culture. Investigators will look for the clinical manifestations, radiological and laboratory findings, renal scarring, ESBL-organisms, prevalence, median age, gender, and ethnic background. Participants are divided into two groups: early infancy and late infancy, ESBL UTIs and non-ESBL UTIs, and upper UTIs and lower UTIs. Finally, UTIs ESBL with COVID-19 and without COVID_19.

Study Timeline

• Status Verified: 2022-04
• Study First Submitted: 2022-04-07
• Study First Submitted QC: 2022-11-22
• Study First Posted: 2022-11-29
• Study Start: 2023-03-01
• Primary Completion: 2023-07-01
• Study Completion: 2023-07-20
• Last Update Submitted: 2023-07-24
• Last Update Posted: 2023-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5600

Inclusion Criteria

• All infants with UTIs who had been treated

Exclusion Criteria

• Patient with a mixed urine culture.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ESBL UTI	comparing, prevalence	all infants with UTIs caused by ESBL producing organisms
Non-ESBL UTI	assessment	all infants with UTIs caused by non-ESBL producing organisms
ESBL UTI without COVID-19	evaluation	all infants with UTIs caused by ESBL producing organisms without COVID-19 infection
ESBL UTI with COVID-19	association	all infants with UTIs caused by ESBL producing organisms with COVID-19 infection

Primary Outcome Measures

Name	Time	Method
Assessment risk factors , prevalence, and the relation between ESBL UTI and COVID-19 infection of all infants with ESBL- UTIs	1year

Trial Locations

Locations (1)

Hamad Medical Corporation; 🇶🇦 Doha, Qatar