The effect of inorganic nitrite on endothelial function in ischaemia-reperfusion in the human forearm
Completed
- Conditions
- CardiovascularCirculatory System
- Registration Number
- ISRCTN57823880
- Lead Sponsor
- Record Provided by the NHSTCT Register - 2006 Update - Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Added 27/02/2008:
1. Healthy subjects
2. Aged 18-45
3. Have volunteered themselves and are willing to sign the consent form
Exclusion Criteria
Added 27/02/2008:
1. Healthy subjects unwilling to consent
2. History of hypertension, diabetes or hypertensive on BP measurement
3. Pregnant or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result
4. History of any serious illnesses, including infectious diseases as above
5. Subjects taking systemic medication (other than the oral contraceptive pill)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Added 27/02/2008: Reduction in forearm endothelial dysfunction (responses to acetylcholine) due to ischaemia-reperfusion with pre-ischaemic infusion of sodium nitrite
- Secondary Outcome Measures
Name Time Method Added 27/02/2008: Effect of nitrite on reperfusion