Effect of sodium selenium administration on functional and cognitive scores in ischemic stroke

Phase 3

Recruiting

Conditions: Ischemic stroke.
Cerebral infarction

Registration Number: IRCT20170104031773N3

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients with acute stroke

Exclusion Criteria

Receiving antioxidants constantly (such as vitamin C and E)
Receiving anti-inflammatory drugs constantly(steroids, nonsteroidal anti-inflammatory)
Suffered from HIV and neurodegenerative diseases (e.g. Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, multiple sclerosis)
Systemic diseases such as Diabetes Mellitus, Renal Failure, Malignant Melanoma, Uremia,Myopathy, and Congestive Heart Failure
Loss of consciousness level due to any reason except stroke (such as shock, alcohol consumption or intoxication)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The level of tumor necrosis factor alpha(TNF-a). Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: Blood sample.;The level of superoxide dismutase (SOD). Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: Blood Sample.;The level of glutathione peroxidase(GPx). Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: Blood Sample.

Secondary Outcome Measures

Name	Time	Method
Motor function and verbal. Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: National Institues of Health Stroke Scale Questionnaire.;Cognitive performance. Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: Mini Mental State Examination Questionnaire.;Degree of disability. Timepoint: At the beginning of the study (before the intervention), 1 month after the start of taking sodium selenite. Method of measurement: Modified Rankin Scale Questionnaire.